雨课堂学堂在线学堂云《Pharmaceutical Dosage Form Technology（北京理工大学）》单元测试考核答案

PharmaceuticalDosageForm&Technology第1题Transdermaldeliverywithoutthefirstpasseffect第2题Idealdosageformsshouldnotdeliverthedrugtowhereshoulditgoandreleasesthedrugattherightlocation第3题Idealdosageformsshouldhavethegoodtasteandgoodsmellwithacceptableappearance第4题Idealdosageformsshouldnotbeconvenientandeasyforthepatienttotake.第5题Dosageformscannotdecidephysicalformsofthefinalpharmaceuticalpreparations,theroutesofadministration,thedosingofmedicines.第6题ChinesePharmacopoeia(ChP)2020editionconsistsof()VolumesAIBIICIIIDIV第7题IdealexcipientsshouldstableandpharmacologicallyinertandshouldinteractwiththeAPI.第8题Sublingualdeliveryroutswiththefirstpasseffect第9题Dropscanbeusedasnasaldrugdeliverysystem第10题Tabletscanbeadministeredbysublingualdeliveryrouts.第11题Gaseousdosageformsinclude().ApastesBointmentsCaerosolsDcreams第12题Liquid-Soliddosageformsinclude().AsyrupsBelixirsCsuspensionsDemulsions第13题Semi-Soliddosageformsinclude().ApastesBcreamsCointmentsDtabltes第14题Dosageformshouldnotreflecttherapeuticintentions.第15题Differentmedicinalpreparationscannotbenameddosageformsordrugdeliverysystems.第1题Dissolutiontimelimitsof6piecessoftcapsulesshouldwithin()minsA15B30C60D120第2题Drippingmethodisformakingseamlesscapsules第3题The()ofcapsulessize,the()ofcapsulesvolumeAbigger,smallerBbigger,biggerCsmaller,smallerDsmaller,bigger第4题Advantagesofcapsulesaremaskthebadsmell,decreasethestability第5题CategoryII:()solubility,()permeability.Ahigh,highBhigh,lowClow,highDlow,low第6题Tabletdisintegrationtestforenteric-coatedtablet:nosignofdisintegration,cracking,orsofteningishappeningastricfluidfor()hA1B2C3D4第7题Pancoatingmethodisnotthemostcommonmethodofcoatingtabletsinindustry.第8题Inordertoreducetheextentofaggregationandagglomerationduringthecoatingprocess,()agentsarerequiredfortackypolymersAPlasticizersBadheringCanti-tackingDwetting第9题MostpolymersthatareusedfordelayedreleaseareinsolubleintheacidicstomachpHconditions.第10题Generally,Maximumtabletthicknessis()mmA6B12C10D8第11题Infrareddryingwithhighenergyconsumption第12题Freeze-dryingprincipleisthatmaterialsaredriedbysublimationofwaterunder()temperature&()vacuumconditions.Ahigh,lowBlow,lowChigh,highDlow,high第13题Hot-meltgranulationisnotsuitableforheat-sensitiveAPIs.第14题ThedisadvantagesofdrygranulationislowpressuresusedandtemperaturesgeneratedmaychangepolymorphismsoftheAPI第15题Aballmillisnotclosedcircuitcrushingtype第16题Crushingisbenefitto()thedissolutionrateandbioavailabilityofpoorlysolubledrugsAdecreaseBimproveCunchangeDbad第17题Iftheamountofthebinderissmallandthehumidityislow,thepreparedtabletsare()andeasytodisperse.ArigidBsoftCsolidDgood第18题Buccaltabletscannotavoidmedicinedestroyedbythefirst-passeffectinvivo.第19题MethodstoimprovedrugdissolutionrateistoincreasesurfaceofAPIaccordingtonoyes-Whitneyequation第20题Powderisusuallyusedtotheinfantsandchildrenbecausetheyliketheappearanceofthem.3.6Exercises第1题Therearegenerallytwomethodsforthepreparationofelixirs:solventmethodanddilutionmethod第2题elixirsarestablethansyrups.第3题Coldmeltdissolvingmethodtopreparethesyrupissuitableforthermallystableorvolatiledrugs.第4题Syrupsaresoacceptabletoyoungstersbecausetheirpleasanttaste.第5题Therearetwotypesofsyrups,whicharenonmedicatedsyrupsandMedicatedsyrups.第6题InStokesequation,ifviscosityηisincreasing,makingthesystemunstable.第7题InStokesequation,Ifparticlesdiameterdisbig,itcanreducetherateofsettlingdx/dtandstabilizethesystem.第8题“ForOralSuspension."Somesuspensionsareavailableinready-to-useforms.Theyarealreadydistributedthroughaliquidvehiclewithorwithoutstabilizersandotheradditives.第9题“OralSuspension."And“OralSuspension."AremainlytwotypesofSuspension.第10题Humectantsmaycausingdryness.第11题nonionicsurfactantsareparticularlyusefulasemulsifiersbecausetheyarelesstoxic第12题Emulsionsarethermodynamicallystablesystem.第13题Theextrasubstancesareaddedinaliquidsolventsystemtoimprovethesolubilityoftheinsolubledrugsinsidebyreactingwiththedrugcomponentstoformsolublemolecules.ThisextrasubstanceisHydrotropyagent.第14题Glycerinisimmisciblewithbothwaterandalcohol.第15题Partsofsolventrequiredfor1partofsoluteis50,thatisslightlysoluble4.7Exercises第1题Watercontentoffinalfreeze-driedsterilizedpowderforinjectionproductsishigherthanexpected.Becauseinsufficientheatsupplyduringthesublimationdryingprocess.第2题Preparationprocessoffreeze-driedsterilizedpowderforinjectionproductsisperformedinthreesteps:Pre-freezing,Pressuredecreasing,Heating.第3题Large-volumeparenteralsolutions(LVPs)productsshouldphysicalandchemicalstable.第4题Qualitycontrolforlarge-volumeparenteralsolutions(LVPs):OsmoticpressureofLVPsproductsmustbeequaltoplasmaorslightlylowerthanplasma.第5题Inproductionprocessoflarge-volumeparenteralsolutions(LVPs).Fillingandsealingmodulesareperformedin()levelin()levelbackgroundcleanarea.AA,BBA,CCB,CDB,A第6题Prefilledsyringe(PFS)aresafeandwithaccuratedose.第7题Asingle,small-volumeinjection:Involumesof()mL.A1B5C100D1000第8题Injectionsarepainfulwithpoorlycompliance,especiallyforinfantsandchildren.第9题Themovementformsoftheairflowincleanroomsaremainly()flowand()flow.Alaminar,laminarBlaminar,turbulenceCturbulence,laminarDturbulence,turbulence,第10题Mediumefficiencyfilter:filtersoutmorethan()μmSuspendedparticleswithafiltrationeffectof20-70%.A0.1B0.3C1D5第11题Airpurificationtechnologyarevarioustechnologiesthatcancreateacleanairenvironment.第12题Onlyoneproductoutofonemillionproductsisallowedtobecontaminated,indicatingreliablesterilizationeffectiveness.第13题UVradiationisusedfordisinfectionofsurfaces.第14题Flamesterilization:suitableforrefractorymaterials,suitablefordrugsterilization.第15题Pyrogenscanberemovedbyultrafiltrationmembranewithporesizessmallerthan()nm.A1B2C3D0.15.4Exercises第1题Suppositoriesshouldindividuallywrapwithtransparentmaterial.第2题Suppositoriesshouldbestoredandtransportedunder()℃.A20B25C30D35第3题TwoormorevarioustypesPEGscombinedbyfusioncanachieveasuppositorybaseofthedesiredconsistencyandcharacteristics.第4题Suppositoriesaresoliddosageforms第5题Iontophoresisisthechemicalenhancementmethodstoimprovetransdermaldelivery第6题Microneedleisthephysicalenhancementmethodstoimprovetransdermaldelivery第7题SuitabledrugsforTDDSaretherapeuticindexis().AlowBhighCmediumDgood第8题SuitabledrugsforTDDSarehalf-lifelessthan()hour.A1B2C5D10第9题TransdermalDrugDeliverySystemisshortanedasTDDS.第10题Water-removablebasesaremainlyoil-in-water(O/W)emulsions.第11题Absorptionbasesaremainlyoilin-water(O/W)emulsions.第12题Water-solublebasesinclude().AWhitePetrolatumBPolyethyleneglycolsCMineralOilDYellowOintment第13题Ointmentbasesareclassifiedintosomegeneralgroups:().AhydrocarbonbasesBwater-solublebasesCabsorptionbasesDwater-removablebases第14题Medicatedointmentsareusedtoachievethepurposeoftreatment.第15题Ointmentsandsemisolidpreparationsintendedforexternalapplication6.3Exercises第1题SoftMistInhaler(SMI)isthenewtechnologiesforpropellant-freemeteredaerosolproduction.第2题DryPowderInhalers(DPI)cannotavoidusingenvironmentallydetrimentalCFCpropellants.第3题PressurizedMeteredDoseInhalers(pMDI).ItisthemostwidelyusedaerosoldeliverydeviceforthetreatmentofasthmaandChronicobstructivepulmonarydisease(COPD)today.第4题ThelungexhibitsrelativelylowlocalmetabolicactivityandPDDSisnotsuitablefortheadministrationofbioactivemacromolecules.第5题Thebloodflowinthelungisabout()L/minandthedrugcanbeabsorbedquicklyafterpulmonaryadministration.A2B3C4D5第6题Thelungisthemostabundantcapillariesorgancontainsapproximately300millionalveoliwithasurfaceareaof()m2.A120B130C140D150第7题Theairwaysareoftendescribedasthepulmonarytree.Thetreemaybeviewedasaseriesofdividingpassagewaysoriginatingatthetracheaandterminatingatthealveolarsacs.第8题PulmonarydrugdeliverysystemisshortenasPDDS.第9题Thefunctionofthevalveassemblyistodecidepermittheexpulsionofthecontentsofthecaninthedesiredform,atthedesiredrate第10题Propellantisthepowerofsprayingthedrug,sometimescombinedwiththesolventeffectofthedrug第11题Liquefiedgasoramixtureofliquefiedgasesarefrequentlyservingaspropellantandsolvent.第12题Thevaporpressureofpropellantsatroomtemperatureislowerthanatmosphericpressure.第13题Propercontentsasafinemistwithparticles()µmwilltreatmentofasthma,andthoselessthan()µmtreatmentofemphysema.A1,1B1,5C5,5D5,17.3Exercises第1题Oralcolon-specificdrugdeliverysystems(OCDDS)aremostlyenteric-coatedcontrolledreleasedosageforms.第2题Theshelloftime-controlledpulsincapdeliverysystemismadeofwater-solublepolymer.第3题Theosmoticpumppulsereleasetypechronopharmacologicdeliverysystemutilizeseffectofpulse.第4题Thebasiccompositionoftheconventionalosmoticpumpchronopharmacologicreleasesystemisacore,asemi-permeablemembranecoatinglayerandadrugreleaseorifice.第5题Oralchronopharmacologicdrugdeliverysystemreducethetoxicsideeffectsofthedrugandthebesttherapeuticeffectcanbeachieved.第6题GastricacidsecretionincreasesatnightinpatientswithgastriculcersisChronopharmacology.第7题Chronopharmacologyisaboutthesignificantcyclicalrhythmchangesinthehumanbaody.第8题Ifthedrugabsorptionsiteismainlyinthestomachandsmallintestine,extended-releaseformulationshouldbedesignedasapreparationtoadministrateonceevery()hours.A6B12C10D24第9题Drugabsorptionfromdifferentregionsofthegastrointestinaltractisdifferent.第10题Forpoorlyabsorbeddrugs,inadditiontoprolongingtheresidencetimeinthegastrointestinaltract,absorption____canalsobeused.第11题Ifthedrugisabsorbedinthecolon,itispossibletoincreasethedurationofdrugactionto()hours,therebyitcanbedesignedasanextended-releaseformulationadministeredonceaday.A6B12C10D24第12题drugswithahalf-lifeofmorethan()hourarenotsuitableforextended-releasepreparations;A6B12C10D24第13题drugswithahalf-lifeoflessthan()hourarenotsuitableforextended-releasepreparations;A1B2C3D4第14题Itisgenerallyconsideredthat（）gisthemaximumdoseforasingleadministrationofanextended-releasedeliverysystems.A1B2C3D4第15题Themainpurposeofdesignforextended-releaseformulationisusuallytomaintainthebloodconcentrationwithinavalidrangeforalongtime.8.3Exercises第1题Antibody-mediatedtargetingisakindofActiveTargetingSystems第2题Receptor-mediatedtargetingisakindofpassiveTargetingSystems第3题Peptide-mediatedtargetingisakindofPassiveTargetingSystems第4题Antibody-mediatedtargetingisakindofPassiveTargetingSystems第5题LiposomesisDrug-loadedvesiclescomposedofalipidlayer.第6题Drugscanencapsulatedincarrierssuchaslipids,proteins,orbiomaterials,formingcolloidalorsuspendedmicroparticleformulations.第7题PD-1pathway,amajorcheckpointpathway