9β-10β-epoxy-Hexahydrocannabinol-9β-10β-EHHC-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE9β,10β-epoxyHexahydrocannabinolCat.No.:HY-179436CASNo.:1781270-07-2Synonyms:9β,10β-EHHC;9β,10β-epoxyHHC分⼦式:C₂₁H₃₀O₃分⼦量:330.46作⽤靶点:CannabinoidReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性9β,10β-epoxyHexahydrocannabinol⼀种⼤⿇素受体1(CB1)和CB2受体配体，对CB1的结合亲和⼒为224nM，对CB2的结合亲和⼒为335nM。9β,10β-epoxyHexahydrocannabinol可降低⼩⿏的⾃发活动能⼒、诱导僵住症、降低体温并产⽣镇痛作⽤。9β,10β-epoxyHexahydrocannabinol可⽤于神经系统疾病的研究[1]。IC50&TargetCB1CB2224nM(Ki)335nM(Ki)体外研究9β,10β-epoxyHexahydrocannabinolbindstohumanCB1andCB2receptorswithaffinitiesof224nMand335nM,respectively[1].体内研究9β,10β-epoxyHexahydrocannabinol(5-20mg/kg;i.p.;singledose)exertspotentcannabimimetic-likeeffectsinhealthymice,includinghypolocomotion,catalepsy,antinociception,andhypothermia[1].AnimalModel:SwissWebster(male,8weeksold,24-30g)[1]Dosage:5,10,20mg/kgAdministration:i.p.;singledoseResult:Causedsignificanthypolocomotion,significantcatalepsy(latencyincrease),significanthot-plateantinociception,andasignificantdecreaseinrectaltemperature.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEREFERENCES[1].RadwanMM,etal.IsolationandPharmacologicalEvaluationofMinorCannabinoidsfromHigh-PotencyCannabissativa.JNatProd.2015;78(6):1271-1276.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>