catosal科特壮-犬猫疾病支持治疗药物

1、科特壮 犬猫疾病支持治疗药物 刘久占德国拜耳,The Power of Pink,支持治疗,支持治疗是指与特异性疗法配合的附加治疗, 它可以缩短犬猫疾病的康复时间！,支持治疗,支持治疗是指与特异性疗法配合的附加治疗, 它可以缩短犬猫疾病的康复时间！,支持治疗对犬猫的重要性,一般来说，疾病会降低犬猫新陈代谢机能，而新陈代谢机能降低又会延缓犬猫的康复。临床上特异性治疗不会恢复患病犬猫的新陈代谢机能。所以促进新陈代谢的支持治疗性药物会明显促进患病宠物的康复。,患病犬猫需要额外的能量来帮助疾病康复,总结,简而言之:患病动物需要更多的能量: 正常的身体功能需要 从疾病中快速康复

2、,支持治疗形式,平衡营养 充足休息 注意管理 增加多种维生素和矿物质 保护肝脏等,ENERGY,脂类和糖类最终利用的形式 (ATP),ATP 变成ADP并释放细胞利用的能量 (如:提供给肌肉细胞),能量的利用方式,能量重要的因素,整个新陈代谢过程关键因素是磷元素的代谢,磷元素在AMP-ADP-ATP循环后,有部分会流失掉,理论上,磷元素加入到ADP分子中是提供能量储备的最好方式,能量 理想的支持治疗,磷会流失,需要不断补充,提供含能量储备的磷能帮助细胞更好的工作!,随着能量需求的增加,富含能量的磷混合物可以满足新陈代谢的需求,CATOSAL就是答案,每 ml含量: 布他磷 100.00 mg

3、Vit B12 0.05 mg Methyl paraben 1.00 mg,Phosphorus content: 17.3 mg/ml,提供磷元素,提供维生素,其他,作用成分,磷含量: 17.3 mg/ml,Catosal 疾病支持治疗的关键,科特壮的成分,布他磷,有机磷酸 无味的白色晶体,VB12,科特壮的成分,布他磷,无味的白色晶体,作用机理 通过促进ADP-ATP循环，促进机体能量 代谢。 促进机体的合成代谢过程。 激活犬猫机体非特异性免疫反应 恢复疲劳肌肉功能。,缓解应激 / 降低激素水平,De Groot J., van Der Werf J., van Reenen C., S

4、chuurman T., Schmidt B. (2003) : The effect of butafosfan (component of Catosal) on psychosocial stress in pigs. J. Vet. Pharmacol. Therap. 26 (Suppl. 1), 222-223. Van der Staay J., De Groot J., Schmidt B., Schuurman T. (2006) : Effects of Catosal on the physiological and behavioral response to soci

5、al stress in piglets. Proceedings of the 19th IPVS Congress, Copenhagen, Denmark, Volume 2. Simon F (1990) : Study on stress reducing effect of butafosfan in sheep. Institut fr Pharmakologie und Toxikologie, Veterinrmedizinische Universitt, Budapest, Hungary. Bayer ID 12765. Hnsel A., Fuhrmann H., S

6、allmann H.-P, Klee W. (1992) : Infusion von Propionate and Butyrat als Belastungstest zur berprfung mglicher Butafosfanwirkungen auf den Energiestoffwechsel des Rindes. Berl. Mnch. Tierrztl. Wschr. 105, 361-366. Hasi Su-rong, DU Xiao-yan, ZHU Bei-lei, JIANG Jin-shu (2004a): Studies on Effects of Com

7、pound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice. Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294.,降低冷热刺激,Stress Reduction / control of cortisol increase,.,布他磷作用于组织缺氧,Hasi Su-rong et al. (2004a),*p:0.05, *p:0.001 compared to control group,*,*,存活时间 (分钟),High

8、 dose butaphosphan (n=12) : 250 mg/kg butaphosphan once a day for 7 days orally. Low dose butaphosphan (n=12) 125 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12): 10 ml/kg physiologic saline once a day for 7 days oral. One hour after treatment on the last day, each mouse was pl

9、aced In a 300 ml wide-mouthed flask which was sealed with transparent glad wrap That did not admit air and timing was commenced. With the termination of breathing as the endpoint, the time for each mouse to expire from lack of oxygen was noted, so as to determine the effect of butaphosphan on the to

10、lerance of mice hypoxia.,刺激能量产生,参考资料: Hasi Su-rong, DU Xiao-yan, ZHU Bei-lei, JIANG Jin-shu (2004a): Studies on Effects of Compound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice. Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294. HASI Su-rong , JIANG Jin-shu, DU

11、 Xiao-yan, ZHU Bei-lei (2005a): Anti-cold stress effects and mechanisms of compound butaphosphan solution. Progress in Veterinary Medicine, 26, (03), 59-62. HASI Su-rong , JIANG Jin-shu , ZHU Bei-lei , DU Xiao-yan (2005b) : Studies on Anti-Heat Stress Effects and Mechanisms of Compound Butafosfan So

12、lution. Acta Veterinaria Et Zootechnica Sinica, 36 (12), 1334-1338.,Experiment 1(n=12): 250 mg/kg butaphosphan once a day for 7 days orally. Experiment 2 (n=12): 125 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12) : 10 ml/kg physiologic saline solution. One hour after last trea

13、tment on the last day, mice were sacrificed and liver glycogen content was determined via spectrometer,Experiment 1(n=12): 250 mg/kg butaphosphan once a day for 7 days orally. Experiment 2 (n=12): 125 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12) : 10 ml/kg physiologic saline

14、 solution. One hour after last treatment on the last day, mice were sacrificed and muscle glycogen content was determined via spectrometer,Butaphosphan treatment group (n=12): 250 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12) : 10 ml/kg physiologic saline solution. One hour a

15、fter last treatment on the last day, mice were sacrificed and muscle ATP content was determined via HPLC.,提高肝脏功能,Studies Frll M., Witteck Th., Gengenbach S., Schmidt B. (2006) : Effects of pre-operative application of butaphosphan and cyanocobalamine on reconvalescence clinico-chemical parameters, a

16、ntioxidavive metabolism and postoperative abomosal emptying in cows with abomosal dislocation. Tierrztl. Prax. 34 (G): 351-356. HASI Su-rong , JIANG Jin-shu, DU Xiao-yan, ZHU Bei-lei (2005a): Anti-cold stress effects and mechanisms of compound butaphosphan solution. Progress in Veterinary Medicine,

17、26, (03), 59-62. HASI Su-rong , JIANG Jin-shu , ZHU Bei-lei , DU Xiao-yan (2005b) : Studies on Anti-heat Stress Effects and Mechanisms of Compound Butafosfan Solution. Acta Veterinaria Et Zootechnica Sinica, 36 (12), 1334-1338. Sommer H., Marx D., und Starker G. (1971) : Studies to reduce reproducti

18、ve disorders in cattle by using Catosal as metaphylaxis. Dtsch. Tierrtzl.Wschr. 78, 593 616. Flasshoff F.-H. (1974) : Clinical and chemical blood serum investigations in cattle and treatment studies with ornithine-aspartate-product HMV 20 and with Catosal for the reduction of fertility and health di

19、sorders. Doctorate Thesis, Tierrztliche Hochschule Hannover, Germany. Marbach W (1980) : Alkalische Phosphatase (AP) und Aspartataminotransferase (AST) des Blutplasmas als Parameter der Kondition von Rennpferden und die Wirkung von Coforta/Catosal auf diese Enzyme. Vet. Med. Nahchr., 12.,CATOSAL: 营养

20、肝脏,谷草转氨酶(ASAT)是一种线粒体内的酶，当肝脏或肌肉损伤或肝脏代谢负担过重是会释放到血液中。 科特壮能促进糖异生的过程，这样减轻肝脏的负担。,0d,1d,2d,3d,post OP,科特壮-药理作用,CATOSAL: 营养肝脏,血液中的游离脂肪酸含量是脂肪代谢的指标，脂肪代谢不好时其含量高 用科特壮治疗后游离脂肪酸含量比未治疗明显降低,Catosal 药理作用,科特壮的成分,VB12,水溶性,提供钴元素 需要不断摄入,作用方式 调节蛋白质、脂类和碳水化合物的新陈代谢 提供钴元素，帮助红细胞合成。 促进蛋氨酸合成，而蛋氨酸是机体蛋白质重要的合成原料。 促进身体生长,提高食物利用率。,黑色晶体,吸水性,科特壮-药理作用,CATOSAL: 抗氧化作用,布他磷是一种-氨基磷酸,可以保护犬猫机体免受氧化损伤。,CATOSAL: 促进生长发育,布他磷能够影响宠物的中间代谢（GIESECKE 1985），主要表现为促进能量代谢、提高蛋白质合成（K