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胸廓出口综合征的诊断 与腔内治疗进展概况 汤尧 胸廓出口综合征 Thoracic outlet sydrome (TOS) Definition:Upper extremity symptoms due to compression of the neurovascular bundle by various structures in the area just above the first rib and behind the clavicle. Arterial TOS(ATOS) 90% -Richard J.Sanders (JOURNAL OF VASCULAR SURGERY 2007) Diagnose Etiology Cervical rib 1% population,70% are in women Anomalous first rib NTOS:Neck trauma,repetitive stress working VTOS:excessive activity with arm ATOS:spontaneously,unrelated to trauma or work 22-year-old dance student ,motor accident caused shoulder injury. Numbness and tingling in the left upper extremity for 2.5y. Symptoms ATOSVTOS Emboli from aneurysm or artery stenosis Ischemia Pallor Coldness Paresthesia Pain in hand( seldom in shoulder or neck) No Raynauds phenomena Subclavin vein obstruction Arm swelling cyanosis Pain Paresthesia in fingers and hands NTOS Pain Paresthesia Weakness Raynauds phenomena Symptoms Diagnose History Symptoms uncertain PE Imaging lConventional arteriography (oldest and most established ) lCT,MRI,Ultrasonography Diagnose Diagnose Treatment-VTOS 25 patients :thrombolysis, 12 with adjunctive PTA, 2 underwent operative decompression. 3 years of follow-up only 28 % were symptom FREE. L okanathan R, Salvian AJ, Chen JC, Morris C, Taylor DC, Hsiang YN. Outcome after thrombolysis and selective thoracic outlet decompression for primary axillary vein thrombosis. J Vasc Surg. 2001;33(4):783 8. 35 patients :non-operatively with thrombolysis and anticoagulation resulted in a 23 % rate of recurrent thrombosis within 13 months post treatment . Lee JT, Karwowski JK, Harris EJ, Haukoos JS, Olcott C. Long-term thrombotic recurrence after nonoperative management of Paget-Schroetter syndrome. J Vasc Surg. 2006;43(6):123643. Treatment-VTOS Stenting the subclavian vein without surgical decompression also generally fails, at rates approaching 100 %. Maintz D, Landwehr P, Gawenda M, Lackner K. Failure of Wallstents in the subclavian vein due to stent damage. Clin Imaging. 2001;25(2):1337. Urschel Jr HC, Patel AN. Surgery remains the most effective treatment for Paget-Schroetter syndrome: 50 years experience. Ann Thorac Surg. 2008;86(1): 25460. Treatment-FRR Decompression of thoracic outlet Treatment-VTOS Thrombolysis followed by surgical decompression :Primary and secondary patency rates at 1 year are 92 and 96 % respectively . In a huge series of 506 extremities treated over the course of 50 years, 96 % of patients were improved during follow-up periods ranging from 1 to 32 years with an average follow-up of 7.2 years. Schneider DB, Dimuzio PJ, Martin ND, Gordon RL, Wilson MW, Laberge JM, et al. Combination treatment of venous thoracic outlet syndrome: open surgical decompression and intraoperative angioplasty. J Vasc Surg. 2004;40(4):599603. Urschel Jr HC, Patel AN. Surgery remains the most effective treatment for Paget-Schroetter syndrome: 50 years experience. Ann Thorac Surg. 2008;86(1): 25460. Treatment-VTOS one recent report did contend that pre-operative thrombolysis provided no benefi t . 45 patients underwent thrombolysis prior to fi rst rib resection , 65 patients were treated with anticoagulation alone before the surgery. at follow-up, 91 % of both groups had patent veins and were free of symptoms regardless of which pre-operative treatment was used. included a large number of patients who presented with subacute or even chronic thrombus. Guzzo JL, Chang K, Demos J, Black JH, Freischlag JA. Preoperative thrombolysis and venoplasty affords no bene fi t in patency following fi rst rib resection and scalenectomy for subacute and chronic subclavian vein thrombosis. J Vasc Surg. 2010;52(3):65862, discussion 623. Treatment-VTOS TIMING of decompressive surgery Delaying operation for 23 months after thrombolysis to reduce the risk of bleeding. Machleder HI. Evaluation of a new treatment strategy for Paget-Schroetter syndrome: spontaneous thrombosis of the axillary- subclavian vein. J Vasc Surg. 1993;17(2):30515, discussion 167. Complications of early-op (even within 24 hours after thrombolysis) is acceptable. Molina JE, Hunter DW, Dietz CA. Paget-Schroetter syndrome treated with thrombolytics and immediate surgery. J Vasc Surg. 2007;45(2):328 34. Thompson JF, Winterborn RJ, Bays S, White H, Kinsella DC, Watkinson AF. Venous thoracic outlet compression and the Paget-Schroetter syndrome: a review and recommendations for management. Cardiovasc Intervent Radiol. 2011;34(5):90310. Treatment-VTOS Stenosis After VTOS Decompression Surgery (7%-64%) Balloon:typically 1014 mm;high pressure non-compliant balloons; cutting balloons Stent:may be needed,not routine treatment. In a study of selective stenting for patients with post-operative stenoses, those treated with angioplasty alone had 100 % patency whereas patency was only 64 % in those treated with stents . Kreienberg PB, Chang BB, Darling 3rd RC, Roddy SP, Paty PS, Lloyd WE, et al. Long-term results in patients treated with thrombolysis, thoracic inlet decompression, and subclavian vein stenting for Paget- Schroetter syndrome. J Vasc Surg. 2001;33 (2 Suppl):S1005. Treatment-ATOS Non clinic trail,only rare case reports. Decompression,bypass, aneurysmal artery replace. Should not be treated with balloon or stent,only for residual disease not addressed with open OP. Brain Daniels,et. al. Arterial Thoracic outlet sydrome. Chest and abdominal conditions.2014. Treatment-ATOS Stent-graft pl

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