DNMT3A 具体为点及相关药物.xls

CureSeq Lung Cancer Panel V1 GeneExonPosition DNMT3A 包含替换 插入 缺失等共计1743种突 变 R882C 2644C T R882G 2644C G R882S R882H 2645G A R882L 2645G T R882P 2645G C 参考文献 1 Mutation and expression analysis of the IDH1 IDH2 DNMT3A and MYD88 genes in colorectal cancer 2 Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small cell lung cancer 3 Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes 4 Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity 5 The genomic complexity of primary human prostate cancer 5 azacytidine 本品系由微生物 Streptoverticillum ladakanus 所产生的嘧啶核苷类似物 亦可用化学方法合成 临床上用于治疗乳腺癌 肠癌 黑色素瘤 急性粒细胞性白血病等有一定疗效 decitabine FDA批准用于骨髓增殖性疾病治疗 不确定是不是DNMT3A抑制剂 lenalidomide FDA批准用于骨髓增殖性疾病治疗 不确定是不是DNMT3A抑制剂 Drugs 5 azacytidine2 CureSeq Lung Cancer Panel V1 参考文献 1 Mutation and expression analysis of the IDH1 IDH2 DNMT3A and MYD88 genes in colorectal cancer 2 Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small cell lung cancer 3 Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes 4 Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity 5 The genomic complexity of primary human prostate cancer 5 azacytidine 本品系由微生物 Streptoverticillum ladakanus 所产生的嘧啶核苷类似物 亦可用化学方法合成 临床上用于治疗乳腺癌 肠癌 黑色素瘤 急性粒细胞性白血病等有一定疗效 decitabine FDA批准用于骨髓增殖性疾病治疗 不确定是不是DNMT3A抑制剂 lenalidomide FDA批准用于骨髓增殖性疾病治疗 不确定是不是DNMT3A抑制剂 Clinical TrialsGrade Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers 在在实实体体瘤瘤中中有有此此突突变变 1 Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers 在实体瘤中有此突变 2 Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms 实验 Mutational analysis was performed in 92 patients with MDS and related disorders who received 5 azacytidine n 55 decitabine n 26 or both n 11 结果 In multivariate analysis TET2 MUT and or DNMT3A MUT P 0 03 platelets or 100 10 9 l P 0 007 and WBC 3 0 10 9 l P 0 03 were independent predictors of better response TET2 MUT and or DNMT3A MUT P 0 04 status was also independently prognostic for improved PFS as were good or intermediate cytogenetic risk P 0 0001 age or 10 g dl P 0 01 Better OS was associated with ASXL1 WT P 0 008 and SF3B1 MUT P 0 01 and similar to PFS cytogenetic risk P 0 0002 age P 0 02 and hemoglobin P 0 04 2级 CureSeq Lung Cancer Panel V1 参考文献 1 Mutation and expression analysis of the IDH1 IDH2 DNMT3A and MYD88 genes in colorectal cancer 2 Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small cell lung cancer 3 Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes 4 Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity 5 T