干燥抗体综述大纲及计划

1、厦门大学我们毕业啦其实是答辩的标题地方综述大纲&来年计划汇报人熊应玲综述大纲题目简介自身抗体分述举例说明总结及展望CONTANTS参考文献“”TitleThe advance of autoantibody in Sjogren syndrome题目简介分述举例参考总结及展望 Sjgrens syndrome (pSS) is one of the most frequent autoimmune systemic diseases, mainly characterized by ocular and oral dryness due to the progressive destructi

2、on of lachrymal and salivary glands by an inflammatory process. A noteworthy proportion of patients also features extraglandular manifestations, sometimes severe and life-threatening1. Introduction题目简介分述举例参考总结及展望Autoantibodies are highly characteristic of Sjogrens syndrome (SS) and represent importa

3、nt tools for studying its pathogenesis and diagnosis.题目简介分述举例总结参考部分自身抗体123TEXT分述题目简介分述举例参考总结及展望主要从产生机制，发病机制，结合的抗原及其表位，在干燥中的特异度和灵敏度，与临床表现及相关治疗的关系等，但由于各个抗体的研究进展不一，可能在抗体时只包括其中的一部分或及部分，而且由于与干燥相关的自身抗体较多，我就只详细的介绍几个，其余的会通过列表形式将其展现出来Exposure to danger or apoptosis-inducing signals leads glandular epithelial

4、 cells (SGECs) expressing the intracellular autoantigenic proteins to discharge SSA、SSB autoantigens to the microenvironment through exosomes or apoptotic bodies. These autoantigen-loaded vesicles are processed by antigen-presenting cells (APCs) and result to the activation of B cells and the genera

5、tion of autoantibody-producing B cells.2The mechanism of anti-SSA and anti-SSB production题目简介分述举例参考总结及展望题目简介分述举例总结参考自身抗体产生机制Multiple studies have showed that patients with positive results for these antibodies have more frequent parotiditis 、extraglandular complications and lymphoma。An analysis of 3

6、21 patients with pSS showed that those with organ involvement had in 65% anti-Ro52 and antiRo60 antibodies, whereas the non-organ group had 57%. The occurrence of anti-La/SSB was also greater in the organ-affected group，about 48%. Another analysis showed that patients with pSS and non-Hodgkin lympho

7、ma only 37% were Ro/SSA and 50% La/SSB positive.3Association with clinical cours and correlation proportion题目简介分述举例参考总结及展望A treatment that eliminates these abnormal B cells (preventing the appearance of extraglandular manifestations and progression toward malignancy) promises as a disease-modifying

8、drug in primary Sjgrens syndrome. Until now, patients enrolled in these trials need to be positive to anti-Ro/SSA antibodies and/or rheumatoid factor.Nevertheless, the positivity and the titers of anti-Ro/SSA antibody do not change after the treatment. Thus, the anti-Ro/SSA antibody helps in selecti

9、ng patients who are most likely to benefit, however it is not used as a serologic outcome.3 Association with treatment题目简介分述举例参考总结及展望题目简介分述举例参考总结及展望Conclusions结合自己所看文献，总结目前取得的进展和尚未解决难题，还希望自己能通过查阅文献，提出合理展望，做出大胆的假设（不过就目前自己的水平来说，估计有点难），由于目前看的文献少，这里就不做总结啦11 Divi Cornec a,b, Christophe Jamin b, Jacques-O

10、livier Pers. Sjgrens syndrome: Where do we stand, and where shall we go? Journal of Autoimmunity 51 (2014) 109e114.2Nikolaos C. Kyriakidis, Efstathia K. Kapsogeorgou, AthanasiosG. Tzioufas. A comprehensive review of autoantibodies in primary Sjgrens syndrome: Clinical phenotypes and regulatory mecha

11、nisms. Journal of Autoimmunity 51 (2014) 67-74.23 Gabriela Hernndez-Molina , Gustavo Leal-Alegre, Martha Michel-Peregrina. The meaning of anti-Ro and anti-La antibodies in primary Sjgrens syndrome. Autoimmunity Reviews 10 (2011) 123125.3题目简介分述举例参考总结及展望Reference来年计划TEXT学习实验理论、技 术 ， 如 PCR、we s te r n 、ELISA 等等。TEXT更加广泛的阅读文献，找到自己感兴趣的研究方向。更加广泛的阅读文献，找到自