医学免疫学英文版课件：chapter 6 CD-adhesion moleculars

1、 Chapter 6CD and Adhesion MoleculesIntroductionMembrane molecules of immune cell Definition of leukocyte differentiation antigen and CD Definition,classification and functions of adhesion moleculesClinical application of CD and adhesion moleculesPart I Membrane molecules of immune cell Receptors:TCR

2、,BCR,CR,CKR,FcRClass I and class II MHC moleculesCD molecules:CD1-247Adhesion moleculesPart II Definition of leukocyte differentiation antigen and CDLeukocyte differentiation antigen:Cell surface molecules expressed (or disappeared) on different developmental and differential phases of blood cells .

3、CD: cluster of differentiation. The same differentiation antigen recognized by different monoclone antibody from different lab are called CD. CDs which take part in T cell recognition,adhesion and activation CDs which take part in B cell recognition,adhesion and activationPart III Definition,classif

4、ication and functions of adhesion moleculesI. DefinitionII. ClassificationIII. Functions I. DefinitionCell adhesion molecules (CAMs) are cell surface proteins involved in the binding of cells to each other or to extracellular matrix.CAMs take effect by the binding of receptor and ligand. II. Classif

5、icationImmunoglobulin (Ig) superfamilyIntegrin family Selectin family Cadhesion family 1. Ig superfamily(IgSF) The structure of these adhesion molecules resemble that of Ig. Members of the Ig superfamily also include: Intercellular adhesion molecules (ICAMs) Vascular-cell adhesion molecule (VCAM-1)

6、2. Integrin familyIntegrins consist of and chains (subunits).According to subunits,Integrins are divided into eight groups: 1- 8VLA-extracellular matrix proteins LFA-1-ICAM-1,2,33. Selectin familySelectins consist of one peptide chain.The three family members include: endothelial (E)-selectin, leuko

7、cyte (L)-selectin, and platelet (P)-selectin. Ligand of selectins is maily sialyl-Lweisx(sLex) or similar structure expressed on leukocyte,endothelial cell and some tumor cells.III. Functions1.Act as co-receptor and co-stimulatory signal during the recognition and activation of immune cells.2. Parti

8、cipate in the adhesion of leukocyte and vascular endothelial cell during inflammation. sLex起3. Participate in lymphocyte homing.Mature lymphocyte migrate to peripheral lymphoid organsRecirculation of lymphocytesLymphocyte migrate to the sites of inflammation Part IV Clinical application of CD and adhesion moleculesElucidating pathological mechanism of diseaseApplication during diagonosis of diseaseApplication during prevention and treatment of diseaseWhat you should know by the end of