N6-Ethyladenosine - Adenosine Receptor Agonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN6-EthyladenosineCat. No.: HY-111809CAS No.: 14357-08-5分式: CHNO分量: 295.29作靶点: Adenosine Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 83.33 mg/mL (282.20 mM)* m

2、eans soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3865 mL 16.9325 mL 33.8650 mL5 mM 0.6773 mL 3.3865 mL 6.7730 mL10 mM 0.3387 mL 1.6933 mL 3.3865 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液

3、，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.04 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.04 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 M

4、aster of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (7.04 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 N6-Ethyladenosine种腺苷衍物，为腺苷受体 (Adenosine receptor) 激动剂，对 hA1AR 和 hA3AR 的 Ki值分别为 4.9 和 4.7 nM 1。IC50 & Target Ki: 4.9 nM (hA1AR), 4.7 nM (hA3AR) 1体外研究 N6-Ethyladenosine (Compound 28) exhi

5、bits more selectivity at hA1AR and hA3AR over hA2AR (Ki,8900770 nM) 1.REFERENCES1. Kimand SK, et al. Three-dimensional quantitative structure-activity relationship of nucleosides acting at the A3 adenosine receptor:analysis of binding and relative efficacy. J Chem Inf Model. 2007 May-Jun;47(3):1225-33. Epub 2007 Mar 6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02