PYZD-4409-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPYZD-4409Cat. No.: HY-13297CAS No.: 423148-78-1分式: CHClFNO分量: 351.67作靶点: E1/E2/E3 Enzyme作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 35 mg/mL (99.53 mM)* me

2、ans soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.8436 mL 14.2179 mL 28.4357 mL5 mM 0.5687 mL 2.8436 mL 5.6872 mL10 mM 0.2844 mL 1.4218 mL 2.8436 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液

3、，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.11 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 PYZD-4409是泛素激活酶E1抑制剂，IC50为20 uM。户使本产品发表的科研献 Mol Cell Biol. 2018 Ju

4、l 16;38(15). pii: e00024-18.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood.2010 Mar 18;115(11):2251-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02