Ki16425-Debio-0719-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEKi16425Cat. No.: HY-13285CAS No.: 355025-24-0Synonyms: Debio 0719分式: CHClNOS分量: 474.96作靶点: LPL Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (210.54 m

2、M)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1054 mL 10.5272 mL 21.0544 mL5 mM 0.4211 mL 2.1054 mL 4.2109 mL10 mM 0.2105 mL 1.0527 mL 2.1054 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内

3、实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.26 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.26 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师

4、www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.26 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Ki16425 (Debio 0719)是竞争型，亚型选择性的EDG-家族受体 LPA1 和 LPA3 的拮抗剂，Ki 分别为 0.34 M和0.93 M。REFERENCES1. Ohta H, et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid

5、receptors.Mol Pharmacol, 2003, 64(4), 994-1005.2. Moughal NA, et al. Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neuriteoutgrowth in pheochromocytoma 12 cells. J Neurochem, 2006, 98(6), 1920-1929.3. Ma L, et al. Evidence for lysophosphatid

6、ic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experimentsusing Ki-16425, a lysophosphatidic acid 1 receptor antagonist. J Neurochem, 2009, 109(2), 603-610.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820