消化性溃疡形成的原因,英文课件

ThecausesaboutPepticUlcer

消化性溃疡的形成原因武汉大学causes

aggressivefactors↑

defensive

factors

↓

pepticulceroccurAggressiveFactors

3.Gastricacidandpepsin(胃酸与胃蛋白酶)2.Adverseeffectsofdrugs,suchasNSAID1.Helicobacterpyloriinfection(幽门螺杆菌感染)4.others2.NSAID

AfterH.pinfection,NSAIDisthenextimportantcause

.

ResearchdatashowthatNSAIDuseinpatientswithpepticulcerandtheriskofcomplicationswassignificantlyhigherthanthegeneralpopulation.Byweakeningmucosaldefenseandrepairfunctionseventuallyleadtopepticulcer.

案例展示3.Acidandpepsin

Theeventualformationofpepticulcerisdueto

acidandpepsindigestionofthemucosaitself.

Becausethebiologicactivityof

pepsinis

depended

onthepHvalue.WhenlocalpHvalueelevatesto4,pepsincan’tworkwell.Soweoftensaythat“Noacid,noulcer.”

4.Otherriskfactors1)Smoking

Smokingisanincreasedriskofpepticulcer.Smokingcanaffectthehealingofulcer,accelerateulcerrecurrence,andincreasedcomplicationofulceration.Butthemechanismisn’tclear.

3)Stress

Highstresscanstimulatevagusnerve(交感神经),whichcanresult

inhighsecretionofacid.DefensiveFactors2.MucosaBarrier（粘膜屏障）

1.Mucus/BicarbonateBarrier（粘液、碳酸氢盐屏障）3.MucosalBloodFlux（胃粘膜血流屏障）4.Others2.MucosaBarrierThesecondlineofdefenseistheintrinsicepithelialcelldefense（上皮细胞防御、粘膜屏障）

Themucosalsurfaceisabarriertoacidbackdiffusionthusmaintainingnormal

intracellular（细胞内）pH.3.MucosalBloodFluxThethirdlineofdefenseistherichmucosalbloodflow(丰富的粘膜血流屏障).

Thebloodprovidesabufferforacidneutralization（中和）aswellasadequatenutritionforthemetabolic（代谢）demandtomaintainmucosalintegrity.4.Others

Prostaglandin(前列腺素),canreducethesecretionofacid.Feedbackregulationofgastricsecretion.（胃的分泌的反馈调节）conclusionwhenthebala