用中医治疗艾滋病

用中医治疗艾滋病第1页/共75页/FCKeditor/UserFiles/Image/spectroscopyNOW_ezines_2005/Journal_Articles/HIV_virus_200011005.jpg第2页/共75页Objective

TointroducetheetiologyandpathophysiologyofAIDSfromabiomedicalandChineseMedicalperspectiveusingportionsoftheClassicsandmodernclinicaldiscussion,TodiscussthemostfrequentlyseenclinicalpresentationsofAIDS,Tointroduceclinicallyrelevantherbaltreatmentmethodsforthesepresentations.第3页/共75页PandemicAIDSisachronic,incurable,viraldiseasewhichdestroysthebody’sadaptive(acquired)immunesystem,leavingitvulnerabletomyriadopportunisticinfections.HIV(HumanImmunodeficiencyVirus),thevirusthatcausesAIDS,istransmittedviabodyfluids(blood,semen,vaginalfluid,pre-ejaculate,breastmilk)fromoneinfectedpersontoanother.Modesoftransmission:unprotectedsexualintercourse,IVneedlestick,MTCT(mothertochildtransmissionviabirth&breastfeeding).第4页/共75页SomeSoberingAIDSStatisticsGlobally,between33.4and46millionpeoplecurrentlylivewithHIV.†UNAIDSandtheWHOestimatethatAIDShaskilledmorethan25millionpeoplesinceitwasfirstrecognizedin1981,makingitoneofthemostdestructiveepidemicsinrecordedhistory.†Morethan64%ofallpeoplelivingwithHIVareinsub-SaharanAfrica,asaremorethanthreequarters(76%)ofallwomenlivingwithHIV.†InNorthAmerica,anestimated1.4millionpeopleareinfected.*TheU.S.had1.2millionpeoplelivingwithHIVlastyear.TheU.S.thereforeranksamongthetop10countriesintermsofinfectedpeople.**/article/20061121/D8LHEU000.html†/wiki/AIDS/2006/08/16/2006-08-16T165106Z_01_NOOTR_RTRIDSP_2_OUKTP-UK-AIDS-TREATMENT.jpg第5页/共75页/wiki/Image:HIV_Epidem.pngPrevalenceofAdultHIVInfectionWorldwide,2005(JointUnitedNationsProgramonHIV/AIDS)第6页/共75页WhatexactlyisImmunity?Strictdefinition:“Nonsusceptibilitytotheinvasiveorpathogeniceffectsofforeignmicroorganisms,ortothetoxiceffectofantigenicsubstances.”1“Aconditionofbeingabletoresistaparticulardisease,especiallythroughpreventingdevelopmentofapathogenicmicroorganism,orbycounteractingtheeffectsofitsproducts.”21–/omd.asp?q=immunity2-/medlineplus/mplusdictionary.html第7页/共75页HIV/AIDS&Immunity

InordertounderstandthepathomechanismofHIV/AIDS,weneedtounderstandthebasicsoftheimmunesystem.第8页/共75页StructureoftheImmuneSystemIMMUNESYSTEMINNATEIMMUNITYGenericImmunitycommontoallanimalandplantlife.Immediatedefenseagainstinfection.Short-termprotection.ACQUIRED(ADAPTIVE)IMMUNITYImmunitywith‘memory’thatprovideslong-lastingprotectionforthehostagainstfuturepathogens.NATURALLYARTIFICIALLYMATERNAL(PASSIVE)INFECTION(ACTIVE)ANTIBODYTRANSFER(PASSIVE)IMMUNIZATION(ACTIVE)第9页/共75页AcquiredImmunity

Cell-MediatedImmunity:theaspectoftheimmunesystemthatinvolvestheactivationofmacrophages,naturalkiller(NK)cells,specificcell-destroyingT-lymphocytes,andthereleaseofvarioussecretionsinthedefenseofthehostagainstapathogen.Immunitywith“memory.”Inordertofunctionproperly,thecell-mediatedimmunesystemreliesuponthechemicaldirectionofthe

T-Helper(CD4)cells

tohuntdownanddestroyinfectiousorganisms.第10页/共75页ImmuneSystemAgents:Interferon

Interferon:naturalproteinsproducedbythecellsoftheimmunesystemofmostvertebratesinresponsetochallengesbyforeignagentssuchasviruses,bacteria,parasites,andtumorcells.Interferonassiststheimmuneresponsebyinhibitingviralreplicationwithinothercellsofthebody.Itcanalsostimulatetheactivityoflymphocytes.第11页/共75页ImmuneSystemAgents:T-Cells

T-Cells:Whitebloodcellsknownaslymphocytesthatplayacrucialroleincell-mediatedimmunity.T-HelperCells,NaturalKillerCells,T-MemoryCells,etc.Thefoundationoftheacquired/adaptiveimmunesystem.T-Helper(CD4)cellsareresponsibleforgoverningtheactivityofotherlymphocytesandassuchareacrucialpartoftheimmunesystem.第12页/共75页ImmuneSystemAgents:Phagocytes

Phagocyte:acellthatingestsanddestroysforeignmattersuchasmicroorganismsordebrisviaaprocessknownasphagocytosis.Theycanalsoinduceapoptosisofnormalandtumorcellsandproduceotherimmunestimulating/modulatingsubstances.The“frontline”ofthebody’sdefensesagainstimmuneinfection.第13页/共75页HIV&T-Helper(CD4)CellsHIV,thevirusthatcausesAIDS,replicatesitselfbyinvadingahostT-HelperCell,exploitingitsgeneticmaterial,reproducingviralreplicatesofitself,andkillingthehostcellintheprocess.Withoutadequatenumbersof T-HelperCells,thebody’scell-mediatedimmunesystemfailsandopportunisticinfectionsproliferate.

Astheviruscontinuestoreproduce,moreT-Cellsaredestroyed,ultimatelyleadingtotheircompleteannihilationandthefunctionaldestructionoftheentireimmunesystem./Chemistry/Chem101/hiv/tcells-hiv.jpg第14页/共75页HIVTransmission

MechanismT-Helper(CD4)CellHIVParticle第15页/共75页HIVViralLoadvs.CD4+TLymphocyteCountOvertheUntreatedCourseofDisease/wiki/Image:Hiv-timecourse.png___CD4+TLymphocytecount(cells/mm³)

___HIVRNAcopiespermLofplasma第16页/共75页TheStagesofAIDS

In1990,theWorldHealthOrganization(WHO)groupedtheseinfectionsandconditionstogetherbyintroducingastagingsystemforpatientsinfectedwithHIV-1.Mostoftheseconditionsareopportunisticinfectionsthatareeasilytreatableinhealthypeople.StageI:HIVdiseaseisasymptomaticandnotcategorizedasAIDSStageII:includesrecurrentupperrespiratorytractinfectionsStageIII:includesunexplainedchronicdiarrheaforlongerthanamonth,severebacterialinfectionsandpulmonarytuberculosisStageIV:includestoxoplasmosisofthebrain,candidiasisoftheesophagus,trachea,bronchiorlungsandKaposi'ssarcoma;thesediseasesareindicatorsofAIDS.

第17页/共75页AIDScannotbecured,onlymanagedviaacomplexcocktailofpharmaceuticaldrugswhichinhibitstheactivityofHIV,preventingitfrompenetratingtheT-Helperhostcellandreplicating.ThistherapyiscalledHighlyActiveAnti-RetroviralTherapy,orHAART.Todate,thisismostwidely-usedtherapyintreatingAIDS.Newdrugsareconstantlyunderdevelopmentbypharmaceuticalcompanies.PrescriptionDrugTherapy–“TheCocktail”第18页/共75页WhatisHAART?

ThedrugcocktailinHAARTincludesProteaseInhibitors,ReverseTranscriptaseInhibitors(NRTI’ssuchasAZT),Non-NucleosideReverseTranscriptaseInhibitors(NNRTI’s),andEntry&FusionInhibitors.InconcertthesedrugsareeffectiveatstabilizingT-Cellcounts(CD4count)andreducingthereplicationofHIV(viralload).However,theyareveryexpensiveandcanhavemanysideeffects.Theymustbetakentogetherinordertowork.第19页/共75页PrescriptionDrugTherapy Side-effectsofHAARTincludefatigue,gastrointestinaldistress,CNSdisorders,peripheralpolyneuropathy,renalproblems,hepatotoxicity,changesinbloodcount,allergies,lacticacidosis,pancreatitis,avascularnecrosis,osteopenia,osteoporosis,etc.

/textbook/nw.htm/commute/image/sleep.jpg第20页/共75页PrescriptionDrugTherapy

HAARTisalsoexpensive. Amonth’ssupplyofthedrugswhichcompriseHAARTcancostbetween$1,000-$1,400USD.Oneyearofdrugtherapyalone(notcountingdoctor’scallsorofficevisits)cancostupto$16,800.第21页/共75页用中医治疗艾滋病HIV/AIDS&ChineseMedicine用中医治疗艾滋病第22页/共75页“Peoplewithstrongzhengqidonotsuccumbtoepidemicinfections.”

(HuangDiNeiJing)第23页/共75页DefiningAIDSinTCMAIDS,(AcquiredImmuneDeficiencySyndrome),isreferredtophoneticallyas艾滋病

(aizibing)inChinese.[1]AIDScanbedefinedinseveraldifferentwaysaccordingtoTCMpatternidentification.BecauseAIDSisa“new”disease,havingonlybeenidentifiedin1981,thereisnospecificresearchonthediseasefromthepastorintheClassics.TCMdoespossessalargebodyofinformationaboutinfectiousdiseasesandepidemics,andwaystodescribethesymptomsofthosesufferingfromAIDS./tidor/www/research/aids_virus_dh.jpg第24页/共75页Terminology

AIDScanbecomparedtootherconditionswhichhavebeencopiouslyresearchedanddocumentedintheChineseMedicalTradition.ChineseMedicineusestheterm“infectiousepidemicdiseases,”疫病(yibing)todescribeepidemicdiseasessuchasAIDS,whicharecausedbyinvadingevils(viruses).TheChinesetermfor“virus”isbingdu

病毒,literally“toxic/poisondisease.”AIDScanalsobethoughtofasa“pestilence,”or“plague.”TheChinesetermforthisis温疫(wenyi).Suchadiseasewasthoughttohavealonglatency,suddenonset,andseveresymptoms.第25页/共75页WenBing

温病Differentiation AccordingtoChineseMedicine,AIDSiscausedbyexternalviralevilsinvadinginwardandtakingadvantageofsomepre-existingdeficiency. Theevilhidesinthexueluo

血络(bloodconnectingvessels)andthe

yingfen

营分(nutritivelevel)likeotherwenrebing

温热病(warmheatdiseases). Thisdiseasecanalsobereferredtoasafuqiwenbing

伏气温病

(hiddenqiwarmdisease).Thisdiseaseisaccompaniedbysymptomsofxulao

虚劳(deficiencytaxation).http://www.cbc.ca/news/sars/gfx/epidemic1.jpg第26页/共75页Symptomsoffuqiwenbing

伏气温病

WeaknessofyuanqiDamagetojing;qiinsufficiencyProgressiveemaciationFatigueNightsweatsPoorappetiteDiarrhea/img/05/0595.gif第27页/共75页ClassicText:JinGuiYaoLue

金柜药锊方论

HanDynastyc.206-220BC

JinGuiYaoLue(“EssentialsfromtheGoldenCabinet”)chapter:“TheTheoryofVacuityTaxation”(xulao虚劳):

“Emptypulse,facecolorpale,facecolorwhite,palpitations,emaciation,inabilitytowalkduetosoreandthinskin,blurredvision,witheredhair,subaxillarylymphadenopthy,nightsweats,loosestools,diarrhea,crampingordistensioninthelowerabdomenorevendiarrheawithundigestedfoodinthestools,nocturnalemissions…”(etc).http:///03oct/02088/images/zhangzhong.jpgZhangZhong-jing150-219A.D.第28页/共75页ClassicText:温疫论WenYiLun

(“TreatiseonWarmEpidemicDiseases”)byWuYao-ke,

MingDynastyc.1642AD “Warmepidemicsarenotcausedbywind,cold,summerheat,ordampnessbutbyastrangesortofqiaffectingthespacebetween

heavenandearth.”

[emphasisadded--referringtoapestilentialqiandnotaclimacticorotherexternalcausativefactor,etc.]

/FOTD/images/coal_bed.jpg第29页/共75页ClassicText:温疫论WenYiLun

(“TreatiseonWarmEpidemicDiseases”)byWuYao-ke,

MingDynastyc.1642ADWuYou-keconsideredepidemicqiinthebodyasapestilentialtoxin

hecalledliqi

疬气.(Infectious)Pathogencanbetransmittedfromonepersontoanother,unlikewind,cold,ordampness.(Communicable)Doesnotmanifestsymptomssoonaftertheexposuretothepathogen.(Latent)Epidemicqiinvades,resides,andlurksinthemembranesource[moyuan

膜原].(Chronic)第30页/共75页OneConceptofImmunityinChineseMedicine/images/biol_01_img0018.jpg“FuZhengYuQuXie”扶正与去邪–Supporttherighteousandeliminatetheevil(pathogen)Fuzheng:supporttherighteousqi,strengthenthebody’sresistance,andimproveimmunefunctionQuXie:eliminate,inhibit,andexpelthediseasecausingfactors(bingyin病因),suchastheAIDSvirus第31页/共75页RootTreatmentofAIDS

FuZhengPeiBen

扶正培本

(SupportingtheRighteous&CultivatingtheRoot)

“Emptinessshouldbesupplementedandfullnessshouldbedrained.”

(LingShu–TheSpiritualPivot). Supporting/assistingtherighteous&cultivatingtherootisindicatedinthecaseofemptinessdamagetotherighteousqi. Treatment:balanceandsupplementthelungs,spleen,&kidneys,improvedeficiencyofqiandblood,yinandyang.第32页/共75页TheConceptofImmunityinTCMSupportingtherighteousenablesthebodytoeliminatetheevil;Eliminatingtheevilsimultaneouslypreservestherighteouswhilegettingridofthepathogen. BothmethodsshouldbeusedinthetreatmentofAIDS.扶正与去邪第33页/共75页CommonlyUsedTreatmentMethodsFuZhengPeiBen

(SupportingtheRighteous&CultivatingtheRoot) --BuPi(SupplementingtheSpleen) --BuShen(SupplementingtheKidneys)QingReJieDu

(ClearingHeat&ResolvingToxins)HuoXueHuaYu

(ActivatingtheBlood&TransformingStasis)扶正培本清热解毒活血化瘀第34页/共75页BuPi–SupplementingtheSpleenInjurytotheSpleen&Stomachisthemostcommoncauseofdeficientrighteousqi.Spleenqiiseasilydamagedbyexternalevils,includingviruses.HerbsthatstrengthentheSpleenalsoimproveimmunity.补脾第35页/共75页BuShen–SupplementingtheKidneysKidneyjingdeficiencycanleadtoweaknessinallotherareasofthebodyandviceversa.AIDSpatientsgenerallypresentwithkidneyyinoryangdeficiency,orwithboth.InKidneydeficientpatients,metabolism,cellularimmunity,andhumoralimmunityarealllowerthaninnormalpatients.Kidneyyinenrichmentcanimprovethebody’simmunitywhileprolongingthesurvivalofantibodies.Kidneyyangenrichmentcanexcitethenervesandhumoralreaction,strengthenbodyresistance,andpromotetheformationofnewantibodies.

补肾第36页/共75页Research

Numerousclinicalstudies,mostfromChina,reportthatCD4cellcountincreaseswhileviralloaddecreasesafterpatientsreceiveChineseMedicaltreatments.

MostseriousAIDSresearchinvolvingChineseMedicineisconductedbyChineseresearchers.第37页/共75页TanzaniaStudy

Awidely-citedstudyconductedbyChineseresearchersinTanzaniausingChineseherbaltherapyshowedpromisingresults. Thestudy,whichbeganin1989andendedin1991,measuredtheeffectivenessofTCMherbalformulasin158infectedpeople.

第38页/共75页TanzaniaStudyResults3casesreportingexcellentresults,36casesreportinggoodresults,24casesreportingpartialeffect.95casesreportednochange,with13deathsattheendofthestudy.7casesattheendofthestudytestednegativeforthevirusonELISAandWesternblottests,withonlyonecaserevertingbacktopositivewithinoneyear.Theresults,whilenotoverwhelminglypositive,suggestthatherbaltherapyhasimmune-modulatingandantiviraleffects,andthatfurtherstudyiswarranted.第39页/共75页TraditionalChineseMedicineTumorHospital,Shenzhen

OBJECTIVE:TostudythetherapeuticeffectofChinesemedicinalherbsonHIVpatients.METHODS:WeadoptedthecombinedChinesemedicinalherbsfortreatment,thechiefcomponentsofwhichistoenhancehumanimmunitywhilelighteningtheclinicalsymptoms.Theclinicalaspects,theCD4,CD8lymphocytenumbersandtheplasmaviralloadofthepatientswerecomparedbeforeandafterthetreatment.RESULTS:Of28patientsexamined,allexperiencedincreasedbodyweight,averageincrease5.4kgaftertreatment.Symptomsabatedcompletelyin7caseshavinglong-timefever,4casesofdiarrhea,2casesoflargescaleskinulcerand1caseofskinrashafteronemonthtreatment.

After5monthsoftreatment,3caseswithlymphadenopathyhadsymptomscompletelyabate;in7additionalcasesthesymptomsdiminishedordecreasedinnumber.CD4lymphocytesincreasedin42.9%and50.0%patientsandviralloaddecreasedin71.4%and80.0%patientsaftertwomonthsandfivemonthstreatmentwithChinesemedicinalherbsrespectively.Takingclinicalsymptomsandlaboratoryindicesintoconsideration,thetotaleffectiverateofChinesemedicinalherbsreached94.0%.CONCLUSION:TheChinesemedicinalherbsusedinthisstudycanobviouslyimproveclinicalsymptoms,increaseCD4lymphocytesanddecreaseserumviralloadofHIVpatients.Source:ZhonghuaShiYanHeLinChuangBingDuXueZaZhi.1999Sep30;13(3):291-4.第40页/共75页BeijingUniversityofTechnology,BeijingOBJECTIVE:ToevaluatethetherapeuticeffectofQuDuZengNingCapsuleonAIDS.METHODS:QuDuZengNingCapsuleisacapsulecontainingextractsfrom4Chinesemedicinalherbs.Totally1,000AIDSpatientsweretreated,amongthem60patientswereclinicallyobservedweekly.Bloodroutinetests,liver,heartandkidneyfunction,X-ray,CD4,CD8cellswereexaminedbeforeandaftertreatmentat1,3,6month.Thepatientsweretreatedwith4capsulest.i.dfor6months.RESULTS:Thesymptomswereimprovedinmostofthepatients,theCD4cellsincreasedfrom115.0to295.2/ulandtheviralload(RNAcopies/ml)inmostpatientsreducedmarkedlyormaintainedatthesamelevel.CONCLUSION:ThesedataindicatedthatQuDuZengNingCapsulewaseffectivefortreatmentofAIDSpatientsSource:ZhonghuaShiYanHeLinChuangBingDuXueZaZhi.2004Dec;18(4):305-7.第41页/共75页ChineseHerbalTherapyandHIV/AIDS中医药治疗与艾滋病第42页/共75页KidneyYin&BloodTonics:ImproveImmunityandProlongAntibodySurvivalShudi,Heshouwu,Nuzhenzi,Gouqizi,Guiban,Biejia,Tianmendong,Sangjisheng,etc./uruns/shenminmen/_Fo-ti.jpg第43页/共75页KidneyYangTonics:Strengthenbodyresistance,andpromotetheformationofnewantibodies.

Yinyanghuo,Bajitian,Xianmao,Roucongrong,Dongchongxiacao,Buguzhi,Suoyang,Duzhong,etc.http://www.anti-aging-pflanzen.de/5edf946c96abacd060119fab4afaef3b_ziegenkraut.jpg第44页/共75页QingReJieDu–ClearingHeat&ResolvingToxinsAIDSisapestilentialinfectiousdiseasecausedbyexternallyinvadingevilsthatcangeneratestagnationandtheaccumulationofhottoxins.Heattoxinsusuallymanifestonthesurface,heformofskineruptions(Kaposi’ssarcoma,boils,macules,etc.)MostAIDSpatientssufferfromdebilitatingfevers,sweating,anddehydration.Treatment:clearheat,resolvetoxinstosupporttherighteousandeliminateevil.Herbswhichclearheatandresolvetoxinsarealsoanti-inflammatory,antiviral,andantibacterial.清热解毒第45页/共75页HerbsforClearingHeat&ResolvingToxinsBecausemostheat-clearing,toxin-resolvingherbsarebothbitterandcold,theyaretraditionallycontraindicatedinxulaodisorders.(Reminder--Xulao:Emptypulse,facecolorpale,facecolorwhite,palpitations,emaciation,inabilitytowalkduetosoreandthinskin,blurredvision,witheredhair,subaxillarylymphadenopthy,nightsweats,loosestools,diarrhea,crampingordistensioninthelowerabdomenorevendiarrheawithundigestedfoodinthestools,nocturnalemissions…”).Bitter&coldherbsmustbecombinedwithsweet,warmherbstosupporttherighteouswhileeliminatingtheevil:simultaneoustreatmentofthedeficiencyandexcess.第46页/共75页HerbsforClearingHeat&ResolvingToxinsClearHeat&Toxicity:Jinyinhua,Lianqiao,Daqingye,Banlangen,Pugongying,XiaKuCao,Huangqin,Huanglian,Huangbai,etc./down/10/1008/PuGongYing/l15.jpg第47页/共75页HerbsforClearingHeat&ResolvingToxinsYeast-Fungalinhibitingfunction:Kushen,Baixianpi,Dahuang,Shegan,Baitouweng,Jiegeng,Yuxingcao,Dingxiang,Shiliupi,Huangbai,Huangqin,etc.第48页/共75页HerbsforClearingHeat&ResolvingToxinsTumorinhibitingfunction:Quanshen,Fenweicao,Banzhilian,Baihuasheshecao,Shemei,Zicao,etc.第49页/共75页HuoXueHuaYu–ActivatingtheBlood&TransformingStasis“[If]qiandbloodarenotharmonious,then100diseaseschangeandarise.”(HuangDiNeiJing黄帝内经).Ifqimoves,bloodmoves.Ifqistagnates,bloodbecomesstatic.BecauseqiandbloodarebothdeficientinAIDSpatients,thebodylacksthestrengthtomovebloodandfluids.Fluidstagnationcanleadtoabdominalmasses,tumors,ascites,lymphedema,etc.Herbsthatmovethebloodcanreducecapillarypermeability,areanti-inflammatory,activatetheabsorptionofinflammation,andregulatetheimmunesystem.Treatment:Invigoratetheblood,transformstasis.活血化瘀第50页/共75页HerbsforInvigoratingtheBloodandDispellingStasis TheseherbsshouldnotbeusedcarelesslyorunnecessarilyinAIDSpatients.Herbstosupplementtheqi(dangshen,huangqi,etc.)shouldaccompanytheseherbstoactivatethebloodbyactivatingtheflowofqi.Usebothdrainingandsupplementingsimultaneously.Chuanxiong,Chishao,Taoren,Honghua,Danshen,Yujin,Sanqi,Yanhusuo,etc./shop/bilder/natur/ligustri.jpg第51页/共75页Revivo:ChinesePatentHerbalMedicineforAIDS

RevivoisanblendofChineseherbswhichhasrecentlygrowninpopularityforthetreatmentofAIDS-relatedopportunisticdiseases.Somelimitedclinicalresearchhasciteditsimmunoprotectiveeffects.Thereisalsoconsiderableanecdotalevidence,yetlarge-scaleclinicaltestshaveyettobeundertaken.Itisadministeredasanherbalpowderaddedtohotwaterandcontains:

Niubangzi牛蒡子(burdockseed) Yiyiren意苡仁(Job’stears) Kugua苦瓜(bittermelon) Hypericumchinensis Lianzi濂子(Lotus) Xiakucao夏枯草(prunella) Dazao大枣(jujubedate) Gancao甘草(licoriceroot)第52页/共75页CBA:Revivovs.HAARTCostofRevivopermonth:$130.42AverageCostofHAARTpermonth:$1,200.00第53页/共75页RevivoviralloadreductionSource:/Medicine/Revivo_viruscount.htm;BeijingHIVHospital第54页/共75页RevivoCD4countincreaseSource:/Medicine/Revivo_CD4count.htm;BeijingHIVHospital第55页/共75页HerbsthatBoosttheZhengQi-Interferon

(PartialListofHerbsthatcanIncreaseProductionofInterferon)

huomaren jinyinhuajuhualianqiaolongyanroumahuangmaimendongmantuoluomudanpimutongqingfengtengrenshenrouguisangyeshanyaoshanzhashengdihuangshengmashudihuangsuanzaorentianmatianmendongwumeiwuzhuyuxiakucaoxiangfuxinyihuaxuanshenyiyirenaiyebaihebaishaobaizhibaizhubanxiabohechaihuchenpichuanbeimudahuangdangguidongguazigancaogegenguadigualouguizhihanfangjihonghuahuaimihuangbaihuanglianhuangqihuangqin第56页/共75页ChineseHerbs&InterferonProduction第57页/共75页HerbsthatBoosttheZhengQi–T-Cells

(PartialListofHerbsthatcanIncreaseProductionofT-Cells)lingzhilugenpugongyingrenshensangjishengsangyeshanyaoshengdihuangshudihuangsuanzaorenwuweiziyinyanghuobaishaobaizhuchaihuchuanxiongdangguidangshenduhuohanliancaoheshouwuhuangqihuangqinjinyinhua第58页/共75页ChineseHerbsandT-CellProduction第59页/共75页HerbsthatBoosttheZhengQi-Phagocytes

(PartialListofHerbsthatcanIncreaseProductionof

PhagocyticLeukocytes)baizhubohebuguzhichuanxiongdaqingyedangguidangshenduhuoduzhonggancaoguizhihangfangjihuangqihuangqinjiegengjinyinhuajuhualingzhimantuoluorenshensangyeshanyaoyinyanghuo第60页/共75页ChineseHerbsandPhagocyticLeukocytes第61页/共75页ChineseHerbsthatStimulatetheProductionofInterferonandT-Cellsbaishao白芍(bloodtonic)chaihu柴胡(coolacridreleaseexterior)shengdihuang生地黄(clearheat/cooltheblood)suanzaoren酸枣仁(nourishheart/calmshen)第62页/共75页ChineseHerbsthatStimulatetheProductionofInterferonandPhagocytesbohe簸荷(coolacridreleaseexterior)gancao甘草(qitonic)guizhi桂枝(warmacridreleaseexterior)hanfangji汉防己(draindampness)juhua菊花(coolacridreleaseexterior)mantuoluo曼陀罗第63页/共75页ChineseHerbsthatStimulatetheProductionofT-CellsandPhagocyteschuanxiong川芎(invigorateblood)dangshen党参(qitonic)duhuo独活(dispelwind-dampness)lingzhi灵芝(nourishheart/calmshen)yinyanghuo淫羊藿(tonifyyang)第64页/共75页ChineseHerbsthatStimulatetheProductionofInterferon,T-Cells,andPhagocytes

baizhu白术(qitonic)danggui当归(bloodtonic)huangqi黄芪(qitonic)huangqin黄亲(clearheat&drydampness)jinyinhua金银花(clearheat&toxicity)renshen人参(qitonic)sangye桑叶(coolacridreleaseexterior)shanyao山药(qitonic)第65页/共75页HerbAnalysisInall3categories,theherbgroupswiththemostactivity(interferon,T-Cells,phagocyticleukocytes)weretonicherbsandherbsthatclearheatorreleasetheexterior.Tonificationandheatclearingmethodsillustratetheeffectivenessofthetreatmentprinciplefuzhengyuquxie

扶正与去邪,supportingtherighteous(tonifying)whileeliminatingtheevil(clearing).

第66页/共75页Redux:EfficacyofHerbsbyType9tonicherbs(alltypes)5releaseexteriorherbs2clearheat/toxicityherbs2nourishheart/calmshenherbs1draindampnessherb1dispelwind-dampnessherb1invigoratebloodherb1miscellaneous(mantuoluo)第67页/共75页TheFutureofTreatingHIV/AIDSUsingChineseMedicine第68页/共75页TheFutureofTreatmentofHIV/AIDS:AMixedBagDoctorsarenowdiscoveringthatcertainpatientsareinfectedwithdrug-resistantstrainsofHIV.Aclusterof4infectedmenwasdiscoveredinKingCounty(Seattle)inJanuary2007.Allareinfectedwithahighlyvirulent,drug-resistantstrainofHIV.ItispossiblethatHIVcancontinuetomutateintomorevirulentstrains,increasingtheirinfectiousnessandresistingalleffortstocontrol/eradicatethem.HIVreversetranscriptasemakesatleastonereplicationerror(mutation)ineveryHIVgenomeperroundofreplicationinacell.ThesuppressionofthevirusbyHAARTisnoguaranteethattheviruswillcontinuetobesuppressed.Chinesemedicinecanprovideanaffordable,sustainablesupportivetreatmentforAIDSHIV/AIDSpatientswhodonorespondtoorwhocannotaffordbiomedicalinterventions.第69页/共75页Relevance?TreatingpatientswithChineseMedicinewillhelpthemfeelbetterandstabilizetheirimmunesystems,therebyimprovingqualityanddurationoflife