临床研究术语标准（CTCAE-v5.0）

MedDRACode,MedDRASOC,CTCAETerm,Grade1

,Grade2

,Grade3

,Grade4

,Grade5

,Definition,NavigationalNote,CTCAEv5.0Change

10002272,Bloodandlymphaticsystemdisorders,Anemia,Hemoglobin(Hgb)<LLN-10.0g/dL;<LLN-6.2mmol/L;<LLN-100g/L,Hgb<10.0-8.0g/dL;<6.2-4.9mmol/L;<100-80g/L,Hgb<8.0g/dL;<4.9mmol/L;<80g/L;transfusionindicated,Life-threateningconsequences;urgentinterventionindicated,Death,"Adisordercharacterizedbyareductionintheamountofhemoglobinin100mlofblood.Signsandsymptomsofanemiamayincludepalloroftheskinandmucousmembranes,shortnessofbreath,palpitationsoftheheart,softsystolicmurmurs,lethargy,andfatigability.",,Clarification:Definition

10005329,Bloodandlymphaticsystemdisorders,"Bloodandlymphaticsystemdisorders-Other,specify",Asymptomaticormildsymptoms;clinicalordiagnosticobservationsonly;interventionnotindicated,"Moderate;minimal,localornoninvasiveinterventionindicated;limitingage-appropriateinstrumentalADL",Severeormedicallysignificantbutnotimmediatelylife-threatening;hospitalizationorprolongationofexistinghospitalizationindicated;limitingselfcareADL,Life-threateningconsequences;urgentinterventionindicated,Death,-,,Clarification:Grade3

10048580,Bloodandlymphaticsystemdisorders,Bonemarrowhypocellular,Mildlyhypocellularor<=25%reductionfromnormalcellularityforage,Moderatelyhypocellularor>25-<50%reductionfromnormalcellularityforage,Severelyhypocellularor>50-<=75%reductioncellularityfromnormalforage,Aplasticpersistentforlongerthan2weeks,Death,Adisordercharacterizedbytheinabilityofthebonemarrowtoproducehematopoieticelements.,,

10013442,Bloodandlymphaticsystemdisorders,Disseminatedintravascularcoagulation,-,Laboratoryfindingswithnobleeding,Laboratoryfindingsandbleeding,Life-threateningconsequences;urgentinterventionindicated,Death,Adisordercharacterizedbysystemicpathologicalactivationofbloodclottingmechanismswhichresultsinclotformationthroughoutthebody.Thereisanincreaseintheriskofhemorrhageasthebodyisdepletedofplateletsandcoagulationfactors.,,

10014950,Bloodandlymphaticsystemdisorders,Eosinophilia,>ULNand>Baseline,-,Steroidsinitiated,-,-,Adisordercharacterizedbylaboratorytestresultsthatindicateanincreasednumberofeosinophilsintheblood.,,Addition:Term

10016288,Bloodandlymphaticsystemdisorders,Febrileneutropenia,-,-,ANC<1000/mm3withasingletemperatureof>38.3degreesC(101degreesF)orasustainedtemperatureof>=38degreesC(100.4degreesF)formorethanonehour,Life-threateningconsequences;urgentinterventionindicated,Death,AdisordercharacterizedbyanANC<1000/mm3andasingletemperatureof>38.3degreesC(101degreesF)orasustainedtemperatureof>=38degreesC(100.4degreesF)formorethanonehour,,

10019491,Bloodandlymphaticsystemdisorders,Hemolysis,"Laboratoryevidenceofhemolysisonly(e.g.,directantiglobulintest;DAT;Coombs';schistocytes;decreasedhaptoglobin)",Evidenceofhemolysisand>=2gdecreaseinhemoglobin,"Transfusionormedicalinterventionindicated(e.g.,steroids)",Life-threateningconsequences;urgentinterventionindicated,Death,Adisordercharacterizedbylaboratorytestresultsthatindicatewidespreaderythrocytecellmembranedestruction.,,Clarification:Grade2

10019515,Bloodandlymphaticsystemdisorders,Hemolyticuremicsyndrome,-,-,"Laboratoryfindingswithclinicalconsequences(e.g.,renalinsufficiency,petechiae)","Life-threateningconsequences,(e.g.,CNShemorrhageorthrombosis/embolismorrenalfailure)",Death,"Adisordercharacterizedbyaformofthromboticmicroangiopathywithrenalfailure,hemolyticanemia,andseverethrombocytopenia.",,Deletion:Grade1

10024378,Bloodandlymphaticsystemdisorders,Leukocytosis,-,-,">100,000/mm3",Clinicalmanifestationsofleucostasis;urgentinterventionindicated,Death,Adisordercharacterizedbylaboratorytestresultsthatindicateanincreasednumberofwhitebloodcellsintheblood.,,

10025182,Bloodandlymphaticsystemdisorders,Lymphnodepain,Mildpain,Moderatepain;limitinginstrumentalADL,Severepain;limitingselfcareADL,-,-,Adisordercharacterizedbyasensationofmarkeddiscomfortinalymphnode.,,

10027506,Bloodandlymphaticsystemdisorders,Methemoglobinemia,-,>ULN,Requiringurgentintervention,Life-threateningconsequences,Death,Adisordercharacterizedbylaboratorytestresultsthatindicateincreasedmethemoglobinintheblood.,,Addition:Term

10043648,Bloodandlymphaticsystemdisorders,Thromboticthrombocytopenicpurpura,-,-,"Laboratoryfindingswithclinicalconsequences(e.g.,renalinsufficiency,petechiae)","Life-threateningconsequences,(e.g.,CNShemorrhageorthrombosis/embolismorrenalfailure)",Death,"Adisordercharacterizedbythepresenceofmicroangiopathichemolyticanemia,thrombocytopenicpurpura,fever,renalabnormalitiesandneurologicalabnormalitiessuchasseizures,hemiplegia,andvisualdisturbances.Itisanacuteorsubacutecondition.",,Deletion:Grade1

10061589,Cardiacdisorders,Aorticvalvedisease,Asymptomaticvalvularthickeningwithorwithoutmildvalvularregurgitationorstenosisbyimaging,Asymptomatic;moderateregurgitationorstenosisbyimaging,Symptomatic;severeregurgitationorstenosisbyimaging;symptomscontrolledwithmedicalintervention,"Life-threateningconsequences;urgentinterventionindicated(e.g.,valvereplacement,valvuloplasty)",Death,Adisordercharacterizedbyadefectinaorticvalvefunctionorstructure.,,

10003586,Cardiacdisorders,Asystole,Periodsofasystole;non-urgentmedicalmanagementindicated,-,-,Life-threateningconsequences;urgentinterventionindicated,Death,"Adisordercharacterizedbyadysrhythmiawithoutcardiacelectricalactivity.Typically,thisisaccompaniedbycessationofthepumpingfunctionoftheheart.",,

10003658,Cardiacdisorders,Atrialfibrillation,"Asymptomatic,interventionnotindicated",Non-urgentmedicalinterventionindicated,"Symptomatic,urgentinterventionindicated;device(e.g.,pacemaker);ablation;newonset",Life-threateningconsequences;embolusrequiringurgentintervention,Death,AdisordercharacterizedbyadysrhythmiawithoutdiscerniblePwavesandanirregularventricularresponseduetomultiplereentrycircuits.Therhythmdisturbanceoriginatesabovetheventricles.,,"Clarification:Grade3,4"

10003662,Cardiacdisorders,Atrialflutter,"Asymptomatic,interventionnotindicated",Non-urgentmedicalinterventionindicated,"Symptomatic,urgentinterventionindicated;device(e.g.,pacemaker);ablation",Life-threateningconsequences;embolusrequiringurgentintervention,Death,Adisordercharacterizedbyadysrhythmiawithorganizedrhythmicatrialcontractionswitharateof200-300beatsperminute.Therhythmdisturbanceoriginatesintheatria.,,"Clarification:Grade3,4"

10003673,Cardiacdisorders,Atrioventricularblockcomplete,-,Non-urgentinterventionindicated,"Symptomaticandincompletelycontrolledmedically,orcontrolledwithdevice(e.g.,pacemaker);newonset",Life-threateningconsequences;urgentinterventionindicated,Death,AdisordercharacterizedbyadysrhythmiawithcompletefailureofatrialelectricalimpulseconductionthroughtheAVnodetotheventricles.,,Clarification:Grade3

10003674,Cardiacdisorders,Atrioventricularblockfirstdegree,"Asymptomatic,interventionnotindicated",Non-urgentinterventionindicated,-,-,-,Adisordercharacterizedbyadysrhythmiawithadelayinthetimerequiredfortheconductionofanelectricalimpulsethroughtheatrioventricular(AV)nodebeyond0.2seconds;prolongationofthePRintervalgreaterthan200milliseconds.,,

10007515,Cardiacdisorders,Cardiacarrest,-,-,-,Life-threateningconsequences;urgentinterventionindicated,Death,Adisordercharacterizedbycessationofthepumpingfunctionoftheheart.,,

10007541,Cardiacdisorders,"Cardiacdisorders-Other,specify",Asymptomaticormildsymptoms;clinicalordiagnosticobservationsonly;interventionnotindicated,"Moderate;minimal,localornoninvasiveinterventionindicated;limitingage-appropriateinstrumentalADL",Severeormedicallysignificantbutnotimmediatelylife-threatening;hospitalizationorprolongationofexistinghospitalizationindicated;limitingselfcareADL,Life-threateningconsequences;urgentinterventionindicated,Death,-,,Clarification:Grade3

10008481,Cardiacdisorders,Chestpain-cardiac,Mildpain,Moderatepain;painonexertion;limitinginstrumentalADL;hemodynamicallystable,Painatrest;limitingselfcareADL;cardiaccatheterization;newonsetcardiacchestpain;unstableangina,-,-,"Adisordercharacterizedbysubsternaldiscomfortduetoinsufficientmyocardialoxygenatione.g.,anginapectoris.",AlsoconsiderCardiacdisorders:Myocardialinfarction.,"Addition:Navigationalnote;Clarification:Grade2,3,Definition"

10010276,Cardiacdisorders,Conductiondisorder,Mildsymptoms;interventionnotindicated,Non-urgentmedicalinterventionindicated,"Symptomatic,urgentinterventionindicated",Life-threateningconsequences,Death,Adisordercharacterizedbypathologicalirregularitiesinthecardiacconductionsystem.,,"Clarification:Grade2,3,4"

10011703,Cardiacdisorders,Cyanosis,-,Present,-,-,-,Adisordercharacterizedbyabluishdiscolorationoftheskinand/ormucousmembranes.,,Addition:Term

10019279,Cardiacdisorders,Heartfailure,"Asymptomaticwithlaboratory(e.g.,BNP[B-NatriureticPeptide])orcardiacimagingabnormalities",Symptomswithmoderateactivityorexertion,Symptomsatrestorwithminimalactivityorexertion;hospitalization;newonsetofsymptoms,"Life-threateningconsequences;urgentinterventionindicated(e.g.,continuousIVtherapyormechanicalhemodynamicsupport)",Death,"Adisordercharacterizedbytheinabilityofthehearttopumpbloodatanadequatevolumetomeettissuemetabolicrequirements,or,theabilitytodosoonlyatanelevationinthefillingpressure.","IfleftsideduseCardiacdisorders:Leftventricularsystolicdysfunction;alsoconsiderCardiacdisorders:Restrictivecardiomyopathy,Investigations:Ejectionfractiondecreased.","Addition:Navigationalnote;Clarification:Grade2,3"

10069501,Cardiacdisorders,Leftventricularsystolicdysfunction,-,-,Symptomaticduetodropinejectionfractionresponsivetointervention,"Refractoryorpoorlycontrolledheartfailureduetodropinejectionfraction;interventionsuchasventricularassistdevice,intravenousvasopressorsupport,orhearttransplantindicated",Death,Adisordercharacterizedbyfailureoftheleftventricletoproduceadequateoutput.,AlsoconsiderInvestigations:Ejectionfractiondecreased.,Addition:Navigationalnote;Clarification:Definition

10061532,Cardiacdisorders,Mitralvalvedisease,Asymptomaticvalvularthickeningwithorwithoutmildvalvularregurgitationorstenosisbyimaging,Asymptomatic;moderateregurgitationorstenosisbyimaging,Symptomatic;severeregurgitationorstenosisbyimaging;symptomscontrolledwithmedicalintervention,"Life-threateningconsequences;urgentinterventionindicated(e.g.,valvereplacement,valvuloplasty)",Death,Adisordercharacterizedbyadefectinmitralvalvefunctionorstructure.,,

10027786,Cardiacdisorders,Mobitz(type)IIatrioventricularblock,"Asymptomatic,interventionnotindicated",Symptomatic;medicalinterventionindicated,"Symptomaticandincompletelycontrolledmedically,orcontrolledwithdevice(e.g.,pacemaker);newonset",Life-threateningconsequences;urgentinterventionindicated,Death,AdisordercharacterizedbyadysrhythmiawithrelativelyconstantPRintervalpriortotheblockofanatrialimpulse.Thisistheresultofintermittentfailureofatrialelectricalimpulseconductionthroughtheatrioventricular(AV)nodetotheventricles.,,Clarification:Grade3

10027787,Cardiacdisorders,MobitztypeI,"Asymptomatic,interventionnotindicated",Symptomatic;medicalinterventionindicated,"Symptomaticandincompletelycontrolledmedically,orcontrolledwithdevice(e.g.,pacemaker)",Life-threateningconsequences;urgentinterventionindicated,Death,AdisordercharacterizedbyadysrhythmiawithaprogressivelylengtheningPRintervalpriortotheblockingofanatrialimpulse.Thisistheresultofintermittentfailureofatrialelectricalimpulseconductionthroughtheatrioventricular(AV)nodetotheventricles.,,

10028596,Cardiacdisorders,Myocardialinfarction,-,AsymptomaticandcardiacenzymesminimallyabnormalandnoevidenceofischemicECGchanges,Severesymptoms;cardiacenzymesabnormal;hemodynamicallystable;ECGchangesconsistentwithinfarction,Life-threateningconsequences;hemodynamicallyunstable,Death,Adisordercharacterizedbygrossnecrosisofthemyocardium;thisisduetoaninterruptionofbloodsupplytothearea.,,

10028606,Cardiacdisorders,Myocarditis,-,Symptomswithmoderateactivityorexertion,Severewithsymptomsatrestorwithminimalactivityorexertion;interventionindicated;newonsetofsymptoms,"Life-threateningconsequences;urgentinterventionindicated(e.g.,continuousIVtherapyormechanicalhemodynamicsupport)",Death,Adisordercharacterizedbyinflammationofthemuscletissueoftheheart.,,"Clarification:Grade2,3;Deletion:Grade1"

10033557,Cardiacdisorders,Palpitations,Mildsymptoms;interventionnotindicated,Interventionindicated,-,-,-,Adisordercharacterizedbyanunpleasantsensationofirregularand/orforcefulbeatingoftheheart.,,

10034040,Cardiacdisorders,Paroxysmalatrialtachycardia,"Asymptomatic,interventionnotindicated",Non-urgentmedicalinterventionindicated,"Symptomatic,urgentinterventionindicated;ablation",Life-threateningconsequences;incompletelycontrolledmedically;cardioversionindicated,Death,Adisordercharacterizedbyadysrhythmiawithabruptonsetandsuddenterminationofatrialcontractionswitharateof150-250beatsperminute.Therhythmdisturbanceoriginatesintheatria.,,"Clarification:Grade2,3"

10034474,Cardiacdisorders,Pericardialeffusion,-,Asymptomaticeffusionsizesmalltomoderate,Effusionwithphysiologicconsequences,Life-threateningconsequences;urgentinterventionindicated,Death,"Adisordercharacterizedbyfluidcollectionwithinthepericardialsac,usuallyduetoinflammation.",,

10053565,Cardiacdisorders,Pericardialtamponade,-,-,-,Life-threateningconsequences;urgentinterventionindicated,Death,Adisordercharacterizedbyanincreaseinintrapericardialpressureduetothecollectionofbloodorfluidinthepericardium.,,

10034484,Cardiacdisorders,Pericarditis,"Asymptomatic,ECGorphysicalfindings(e.g.,rub)consistentwithpericarditis","Symptomaticpericarditis(e.g.,chestpain)","Pericarditiswithphysiologicconsequences(e.g.,pericardialconstriction)",Life-threateningconsequences;urgentinterventionindicated,Death,Adisordercharacterizedbyirritationtothelayersofthepericardium(theprotectivesacaroundtheheart).,,

10061541,Cardiacdisorders,Pulmonaryvalvedisease,Asymptomaticvalvularthickeningwithorwithoutmildvalvularregurgitationorstenosisbyimaging,Asymptomatic;moderateregurgitationorstenosisbyimaging,Symptomatic;severeregurgitationorstenosisbyimaging;symptomscontrolledwithmedicalintervention,"Life-threateningconsequences;urgentinterventionindicated(e.g.,valvereplacement,valvuloplasty)",Death,Adisordercharacterizedbyadefectinpulmonaryvalvefunctionorstructure.,,

10038748,Cardiacdisorders,Restrictivecardiomyopathy,Imagingfindingsonly,Symptomaticwithoutsignsofheartfailure,"Symptomaticheartfailureorothercardiacsymptoms,responsivetointervention;newonsetofsymptoms",Refractoryheartfailureorotherpoorlycontrolledcardiacsymptoms,Death,Adisordercharacterizedbyaninabilityoftheventriclestofillwithbloodbecausethemyocardium(heartmuscle)stiffensandlosesitsflexibility.,,"Addition:Grade1,2;Clarification:Grade3"

10058597,Cardiacdisorders,Rightventriculardysfunction,"Asymptomaticwithlaboratory(e.g.,BNP[B-NatriureticPeptide])orcardiacimagingabnormalities",Symptomswithmoderateactivityorexertion,"Severesymptoms,associatedwithhypoxia,rightheartfailure;oxygenindicated","Life-threateningconsequences;urgentinterventionindicated(e.g.,ventricularassistdevice);hearttransplantindicated",Death,Adisordercharacterizedbyimpairmentofrightventricularfunctionassociatedwithlowejectionfractionandadecreaseinmotilityoftherightventricularwall.,,"Clarification:Grade2,3"

10040639,Cardiacdisorders,Sicksinussyndrome,"Asymptomatic,interventionnotindicated","Symptomatic,interventionnotindicated;changeinmedicationinitiated","Symptomatic,interventionindicated",Life-threateningconsequences;urgentinterventionindicated,Death,"Adisordercharacterizedbyadysrhythmiawithalternatingperiodsofbradycardiaandatrialtachycardiaaccompaniedbysyncope,fatigueanddizziness.",,"Clarification:Grade2,3"

10040741,Cardiacdisorders,Sinusbradycardia,"Asymptomatic,interventionnotindicated","Symptomatic,interventionnotindicated;changeinmedicationinitiated","Symptomatic,interventionindicated",Life-threateningconsequences;urgentinterventionindicated,Death,Adisordercharacterizedbyadysrhythmiawithaheartratelessthan60beatsperminutethatoriginatesinthesinusnode.,,"Clarification:Grade2,3"

10040752,Cardiacdisorders,Sinustachycardia,"Asymptomatic,interventionnotindicated",Symptomatic;non-urgentmedicalinterventionindicated,Urgentmedicalinterventionindicated,-,-,Adisordercharacterizedbyadysrhythmiawithaheartrategreaterthan100beatsperminutethatoriginatesinthesinusnode.,,

10042604,Cardiacdisorders,Supraventriculartachycardia,"Asymptomatic,interventionnotindicated",Non-urgentmedicalinterventionindicated,"Symptomatic,urgentinterventionindicated",Life-threateningconsequences,Death,Adisordercharacterizedbyadysrhythmiawithaheartrategreaterthan100beatsperminutethatoriginatesabovetheventricles.,,"Clarification:Grade3,4"

10061389,Cardiacdisorders,Tricuspidvalvedisease,Asymptomaticvalvularthickeningwithorwithoutmildvalvularregurgitationorstenosis,Asymptomatic;moderateregurgitationorstenosisbyimaging,Symptomatic;severeregurgitationorstenosis;symptomscontrolledwithmedicalintervention,"Life-threateningconsequences;urgentinterventionindicated(e.g.,valvereplacement,valvuloplasty)",Death,Adisordercharacterizedbyadefectintricuspidvalvefunctionorstructure.,,

10047281,Cardiacdisorders,Ventriculararrhythmia,"Asymptomatic,interventionnotindicated",Non-urgentmedicalinterventionindicated,Urgentinterventionindicated,Life-threateningconsequences;hemodynamiccompromise,Death,Adisordercharacterizedbyadysrhythmiathatoriginatesintheventricles.,,"Clarification:Grade3,4"

10047290,Cardiacdisorders,Ventricularfibrillation,-,-,-,Life-threateningconsequences;hemodynamiccompromise,Death,AdisordercharacterizedbyadysrhythmiawithoutdiscernibleQRScomplexesduetorapidrepetitiveexcitationofmyocardialfiberswithoutcoordinatedcontractionoftheventricles.,,Clarification:Grade4

10047302,Cardiacdisorders,Ventriculartachycardia,-,Non-urgentmedicalinterventionindicated,"Symptomatic,urgentinterventionindicated",Life-threateningconsequences;hemodynamiccompromise,Death,Adisordercharacterizedbyadysrhythmiawithaheartrategreaterthan100beatsperminutethatoriginatesdistaltothebundleofHis.,,"Clarification:Grade3,4"

10010331,"Congenital,familialandgeneticdisorders","Congenital,familialandgeneticdisorders-Other,specify",Asymptomaticormildsymptoms;clinicalordiagnosticobservationsonly;interventionnotindicated,"Moderate;minimal,localornoninvasiveinterventionindicated;limitingage-appropriateinstrumentalADL",Severeormedicallysignificantbutnotimmediatelylife-threatening;hospitalizationorprolongationofexistinghospitalizationindicated;limitingselfcareADL,Life-threateningconsequences;urgentinterventionindicated,Death,-,,Clarification:Grade3

10013993,Earandlabyrinthdisorders,"Earandlabyrinthdisorders-Other,specify",Asymptomaticormildsymptoms;clinicalordiagnosticobservationsonly;interventionnotindicated,"Moderate;minimal,localornoninvasiveinterventionindicated;limitingage-appropriateinstrumentalADL",Severeormedicallysignificantbutnotimmediatelylife-threatening;hospitalizationorprolongationofexistinghospitalizationindicated;limitingselfcareADL,Life-threateningconsequences;urgentinterventionindicated,Death,-,,Clarification:Grade3

10014020,Earandlabyrinthdisorders,Earpain,Mildpain,Moderatepain;limitinginstrumentalADL,Severepain;limitingselfcareADL,-,-,Adisordercharacterizedbyasensationofmarkeddiscomfortintheear.,,

10065785,Earandlabyrinthdisorders,Externalearpain,Mildpain,Moderatepain;limitinginstrumentalADL,Severepain;limitingselfcareADL,-,-,Adisordercharacterizedbyasensationofmarkeddiscomfortintheexternalearregion.,,

10019245,Earandlabyrinthdisorders,Hearingimpaired,"AdultsenrolledonaMonitoringProgram(ona1,2,4,3,6,and8kHzaudiogram):Thresholdshiftof15-25dBaveragedat2contiguoustestfrequenciesinatleastoneear;

AdultsnotenrolledonaMonitoringProgram:Subjectivechangeinhearingintheabsenceofdocumentedhearingloss;

Pediatric(ona1,2,3,4,6,and8kHzaudiogram):Thresholdshift>20dBhearingloss(HL)(i.e.,25dBHLorgreater);sensorineuralhearingloss(SNHL)above4kHz(i.e.,6or8kHz)inatleastoneear","AdultsenrolledonaMonitoringProgram(ona1,2,3,4,6,and8kHzaudiogram):Thresholdshiftof>25dBaveragedat2contiguoustestfrequenciesinatleastoneear;

AdultsnotenrolledonaMonitoringProgram:Hearinglosswithhearingaidorinterventionnotindicated;limitinginstrumentalADL;

Pediatric(ona1,2,3,4,6,and8kHzaudiogram):Thresholdshift>20dBat4kHzinatleastoneear","AdultsenrolledonaMonitoringProgram(ona1,2,3,4,6,and8kHzaudiogram):Thresholdshiftof>25dBaveragedat3contiguoustestfrequenciesinatleastoneear;therapeuticinterventionindicated;

AdultsnotenrolledonaMonitoringProgram:Hearinglosswithhearingaidorinterventionindicated;limitingselfcareADL;

Pediatric(ona1,2,3,4,6,and8kHzaudiogram):Hearinglosssufficienttoindicatetherapeuticintervention,includinghearingaids;thresholdshift>20dBat2to<4kHzinatleastoneear","Adults:Decreaseinhearingtoprofoundbilateralloss(absolutethreshold>80dBHLat2kHzandabove);nonservicablehearing

Pediatric:Audiologicindicationforcochlearimplant;>40dBHL(i.e.,45dBHLormore);SNHLat2kHzandabove",-,Adisordercharacterizedbypartialorcompletelossoftheabilitytodetectorunderstandsoundsresultingfromdamagetoearstructures.,,"Clarification:Grade1,2,3,4"

10065838,Earandlabyrinthdisorders,Middleearinflammation,Serousotitis,"Serousotitis,medicalinterventionindicated",Mastoiditis;necrosisofcanalsofttissueorbone,Life-threateningconsequences;urgentinterventionindicated,Death,"Adisordercharacterizedbyinflammation(physiologicresponsetoirritation),swellingandrednesstothemiddleear.",,

10043882,Earandlabyrinthdisorders,Tinnitus,Mildsymptoms;interventionnotindicated,Moderatesymptoms;limitinginstrumentalADL,Severesymptoms;limitingselfcareADL,-,-,"Adisordercharacterizedbynoiseintheears,suchasringing,buzzing,roaringorclicking.",,

10047340,Earandlabyrinthdisorders,Vertigo,Mildsymptoms,Moderatesymptoms;limitinginstrumentalADL,Severesymptoms;limitingselfcareADL,-,-,Adisordercharacterizedbyasensationasiftheexternalworldwererevolvingaroundthepatient(objectivevertigo)orasifhehimselfwererevolvinginspace(subjectivevertigo).,,

10047386,Earandlabyrinthdisorders,Vestibulardisorder,-,Symptomatic;limitinginstrumentalADL,Severesymptoms;limitingselfcareADL,-,-,"Adisordercharacterizedbydizziness,imbalance,nausea,andvisionproblems.",,

10001367,Endocrinedisorders,Adrenalinsufficiency,Asymptomatic;clinicalordiagnosticobservationsonly;interventionnotindicated,Moderatesymptoms;medicalinterventionindicated,Severesymptoms;hospitalizationindicated,Life-threateningconsequences;urgentinterventionindicated,Death,"Adisordercharacterizedbytheadrenalcortexnotproducingenoughofthehormonecortisolandinsomecases,thehormonealdosterone.ItmaybeduetoadisorderoftheadrenalcortexasinAddison'sdiseaseorprimaryadrenalinsufficiency.",,Clarification:Definition

10011655,Endocrinedisorders,Cushingoid,Mildsymptoms;interventionnotindicated,Moderatesymptoms;medicalinterventionindicated,"Severesymptoms,medicalinterventionorhospitalizationindicated",-,-,"AdisordercharacterizedbysignsandsymptomsthatresembleCushing'sdiseaseorsyndrome:buffalohumpobesity,striations,adiposity,hypertension,diabetes,andosteoporosis,usuallyduetoexogenouscorticosteroids.",,

10012205,Endocrinedisorders,Delayedpuberty,-,Nobreastdevelopmentbyage13yrsforfemales;testesvolumeof<3ccornoTannerStage2developmentbyage14.5yrsformales,Nobreastdevelopmentbyage14yrsforfemales;noincreaseintestesvolumeornoTannerStage2byage16yrsformales;hormonereplacementindicated,-,-,Adisordercharacterizedbyunusuallylatesexualmaturity.,,

10014698,Endocrinedisorders,"Endocrinedisorders-Other,specify",Asymptomaticormildsymptoms;clinicalordiagnosticobservationsonly;interventionnotindicated,"Moderate;minimal,localornoninvasiveinterventionindicated;limitingage-appropriateinstrumentalADL",Severeormedicallysignificantbutnotimmediatelylife-threatening;hospitalizationorprolongationofexistinghospitalizationindicated;limitingselfcareADL,Life-threateningconsequences;urgentinterventionindicated,Death,-,,Clarification:Grade3

10018746,Endocrinedisorders,Growthaccelerated,-,>=+2SD(standarddeviation)abovemidparentalheightortargetheight,-,-,-,Adisordercharacterizedbygreatergrowththanexpectedforage.,,

10020705,Endocrinedisorders,Hyperparathyroidism,Mildsymptoms;interventionnotindicated,Moderatesymptoms;medicalinterventioni