Calcitriol-d9-1-25-Dihydroxyvitamin-D3-d-sub-9-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECalcitriol-d9Cat.No.:HY-10002S2CASNo.:1539301-39-7Synonyms:1,25-DihydroxyvitaminD3-d9分⼦式:C₂₇H₃₅D₉O₃分⼦量:425.69作⽤靶点:Isotope-LabeledCompounds;VD/VDR;DrugMetabolite;EndogenousMetabolite作⽤通路:Others;VitaminDRelated/NuclearReceptor;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Calcitriol-d9(1,25-DihydroxyvitaminD3-d9)氘代标记的Calcitriol(HY-10002)。Calcitriol活性最⼤的vitaminD代谢物，也vitaminD受体(VDR)的激动剂。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].WangG,etal.CalcitriolInhibitsCervicalCancerCellProliferationThroughDownregulationofHCCR1Expression.OncolRes.2014;22(5-6):301-9.[2].Santos-MartínezN,etal.Calcitriolrestoresantiestrogenresponsivenessinestrogenreceptornegativebreastcancercells:apotentialnewtherapeuticapproach.BMCCancer.2014Mar29;14:230.[3].DongJ,etal.Calcitriolrestoresrenovascularfunctioninestrogen-deficientratsthroughdownregulationofcyclooxygenase-2andthethromboxane-prostanoidreceptor.KidneyInt.2013Jul;84(1):54-63.[4].ChouCL,etal.Beneficialeffectsofcalcitriolonhypertension,glucoseintolerance,impairmentofendothelium-dependentvascularrelaxation,andvisceraladiposityinfructose-fedhypertensiverats.PLoSOne.2015Mar16;10(3):e0119843.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02