Forsyshiyanine-A-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEForsyshiyanineACat.No.:HY-N17236CASNo.:2767053-65-4分⼦式:C₁₇H₂₅NO分⼦量:259.39作⽤靶点:β-glucuronidase;InfluenzaVirus;RSV作⽤通路:MetabolicEnzyme/Protease;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性ForyshiyanineA⼀种三萜⽣物碱。ForyshiyanineA具有抗炎活性，能够抑制⼤⿏多形核⽩细胞释放β-葡萄糖醛酸酶(β-glucuronidase)。ForyshiyanineA还具有抗病毒活性，对呼吸道合胞病毒(RSV)的EC50值为4.5μM，对甲型H1N1病毒的IC50值为7.3μM。ForyshiyanineA通过⼲扰病毒复制和进⼊来降低病毒载量。ForyshiyanineA可⽤于炎症和感染的研究。体外研究ForsyshiyanineA(Compound1)(10μM)inhibitsthereleaseofβ-glucuronidasefromratpolymorphonuclearleukocyteswithaninhibitionrateof54.5%[1].\r\nForsyshiyanineAexhibitspotentanti-influenzaAvirus(H1N1)activitywithanIC50of7.3μMandshowsgoodanti-respiratorysyncytialvirus(RSV)activitywithanEC50of4.5μM[1].\r\nForsyshiyanineA(0.5-100μg/mL)showsnosignificantcytotoxicitytoMDCKcellswithcellviabilitymaintainedabove80%[1].\r\nForsyshiyanineA(50μM)showsnosignificantcytotoxicityagainstfivehumantumorcelllines(A549lungcancer,A2058melanoma,HepG2hepatoma,MCF-7breastcancer,MiaPaCa-2pancreaticcancercells)[2].\r\nREFERENCES[1].ZhaoL,etal.AlkaloidsbearingrareskeletonsfromForsythiasuspensawithanti-inflammatoryandanti-viralactivitiesinvitro.Phytochemistry.2021;186:112739.[2].RfaishSY,etal.SemisynthesisofForsyshiyanineAandaDerivativewithSignificantAnti-PancreaticCancerActivity.JNatProd.2025;88(11):2781-2788.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02