雨课堂学堂在线学堂云《Pharmaceutics（沈阳药科大学）》单元测试考核答案

Pharmaceutics第1题Thesamedosageformcanhavedifferentdrugs,andthesamedrugcanalsobemadeintomultipledosageforms（)第2题ThefollowingstatementsaboutpharmaceuticaldosageformsarewrongABeforeadrugcanbeusedinclinicaluse,itmustbemadeintoadosageformthatissuitableforapplicationBAdrugcanbemadeintomultipledosageformsCThedosageformofadrugisrelatedtotheclinicalneedDThedosageforminwhichadrugismadedependsonthenatureofthedrugEDosageformscanchangethephysicochemicalpropertiesofdrugs第3题Dosageformsthathavethepotentialtoallowrapidabsorptionofthedrugthroughthemucousmembranestoexertsystemictherapeuticeffectsare:ASublingualtabletsBPatchesCPillsDGranulesECapsules第4题Thetasksofpharmacyare:AResearchanddevelopmentofnewdosageformsBResearchanddevelopmentofnewexcipientsCResearchanddevelopmentofnewdosageformsoftraditionalChinesemedicineDResearchanddevelopmentofbiopharmaceuticalformulationsEResearchanddevelopmentofnewformulationtechnologies第1题Inthecharacteristicsolubilitycurveofthedrug,apositivedeviationindicatesthatthedrugdissociatesinthesolution,orthattheimpuritycomponentsorsolventshaveacompoundingandsolubilizingeffectonthedrug.（）第2题Theforcebetweendrugmoleculesisgreaterthanthatbetweendrugmoleculesandsolventmolecules,andthedrugsolubilityissmall.（）第3题Thesolubilitythatisusuallymeasuredisthecharacteristicsolubilityofthedrug.（）第4题Thereasonwhylatentsolventscanimprovethesolubilityofdrugsisthoughttobethatthereisanassociationbetweenthetwosolvents,whichchangesthedielectricconstantoftheoriginalsolvent.AhydrogenbondBVanderWaalsCcovalentbondDHydrophobicadhesionEConjugatebonds第5题Thefactorsthatarenotrelatedtothesolubilityofthedrugamongthefollowingfactorsare:ATheamountofsolventBtemperatureCPolarityofthedrugDThecrystalformofthedrugEPolarityofthesolvent第6题Thepurposeofmicronizationofpoorlysolubledrugsis:AImproveddissolutionandincreasedbioavailabilityBImprovesthedispersionofthedrugintheformulationCItisconducivetothestabilityofthedrugDReducesirritationofthegastrointestinaltractEImprovethetasteofthepreparation第7题Amongthefollowingfactorsaffecttherateofdrugdissolutionanddissolution:AThedegreeofdispersionofthedrugBtemperatureCTheamountofsolventusedDTypesofsolubilizersEStirringspeed第8题Thefollowingcorrectstatementaboutthesolubilityofadrugis:AThemaximumamountofadrugdissolvedinacertainamountofsolventBThemaximumnumberofgramsofdissolvedsolutein100gofsolvent(or100gsolutionor100mlsolution)atacertainpressureCThenumberofgramsofdissolvedsolutein100gofsolvent(or100gsolutionor100m1solution)atacertaintemperatureDThemaximumnumberofgramsofdissolvedsolutein100gofsolvent(or100gofsolutionor100mlofsolution)atacertaintemperature第9题Phenobarbitalhasthegreatestsolubilityin90%ethanoland90%ethanolisASolubilizerBPolarsolventsCCo-solventsDLatentsolventsENon-aqueoussolvents第10题AccordingtotheNoyes-Whitneyformulaofthedrugdissolutionrateequation,itcanbeconsideredthatundertheconditionofotherfactors,reducingtheparticlesizeofthedrugparticleswillincreasethedissolutionrateofthedrug.Chapter3UnitTesting第1题SurfactantsdonothaveanyofthefollowingeffectsAwettingBemulsifyCSolubilizationDantisepsisEDecontamination第2题Thefollowingsurfactantswiththephenomenonofefficiencyare:ASulfatesBSulfonylationCFattyacidsorbitansDPolysorbatesEPhosphorylides第3题Thefollowingemulsionsthatcanbeusedtoprepareintravenousemulsionsare:AWesternastragalusgumBlecithinCSpan85DSDSEPoloxam188第4题Polysorbate80isacommonlyusedW/Otypeemulsifierinliquidemulsions.第5题ThehighertheHLBvalueofthesurfactant,thestrongerthelipophilicity.ThesmallertheHLBvalue,theweakerthehydrophilicity.Chapter4UnitTesting第1题Benzoicacidismoreeffectiveininhibitingbacteriainacidicsolutions,whilesodiumbenzoateexhibitsbetterpreservativeeffectsinalkalinesolutions.()第2题Thesubstancethatcanincreasethesolubilityofpoorlysolubledrugsiscalledasurfactant.()第3题Theantimicrobialeffectofparabenspreservativesenhanceswiththeincreaseofalkylchainlength,whiletheirsolubilitydecreases.()第4题Thesedimentationvolumeratioisdefinedastheratioofthevolumeofsedimenttothevolumeofthesuspensionbeforesedimentation.()第5题Regardingthequalityrequirementsforliquidpreparations,thefollowingisincorrect:()ALiquidpreparationsshouldbeclearsolutions.BParticlesofthedispersedphaseinheterogeneousliquidpreparationsshouldbesmallanduniform.COralliquidpreparationsshouldhaveanappealingappearanceandpalatabletaste.DMoldgrowthshouldnotoccurduringstorageanduse.ETopicalliquidpreparationsshouldbenon-irritating.第6题Addingasmallamountofelectrolytetoasuspensioncanactas()ASuspendingAgentBWettingAgentCFlocculantorDeflocculantDAntioxidantEEmulsifyingAgent第7题Addingmethylcellulosetocompoundsulfurlotionprimarilyfunctionsas()AEmulsificationBFlocculationCWettingDSuspensionAidEDispersion第8题Thesugarcontent(g/ml)ofsimplesyrupshouldbe()A0.85B0.65C0.6D0.647E0.75第9题Thephenomenonwhereanemulsiontransformsfromonetypetoanotheristermedphaseinversion.()ACreamingBPhaseInversionCPhaseInversionDRancidityERancidity第10题Thepreservativethatexhibitsstronginhibitoryactivityagainstbothmoldsandyeastsamongthefollowingis()ASorbicAcidBPeppermintOilCBenzalkoniumBromideDParabensESodiumBenzoate第11题Theemulsifyingagentsavailableforthepreparationofintravenousemulsionsare()ASodiumLaurylSulfateBOrganicAmineSoapCAcaciaGumDPoloxamer188EPotassiumOleate第12题Amongthefollowingsurfactants,theonegenerallynotusedasasolubilizeroremulsifieris()ABenzalkoniumBromideBPolysorbate80CSodiumLaurylSulfateDSodiumStearateELecithin第13题Liquidpreparationscanbeclassifiedaccordingtothedispersionsystemas()ATrueSolutionBColloidalSolutionCSuspensionDEmulsionEPolymerSolution第14题Thecommonlyusedadjuvantsinliquidpreparationsinclude()APreservativeBFlavoringAgentCAntioxidantDSolubilizerEOxidativeAgent第15题Toenhancethestabilityofsuspensions,commonlyemployedmeasuresinpharmaceuticsinclude()AReducingParticleSizeBIncreasingDensityDifferenceCReducingDensityDifferenceDIncreasingMediumViscosityEDecreasingMediumViscosity第16题Theincorrectstatementregardingsuspendingagentsamongthefollowingis()ASuspendingagentscanincreasetheviscosityofthedispersionmedium.BSuspendingagentscanincreasethedegreeofflocculationinsuspensions.CSuspendingagentscanreducetheζ-potentialofparticles.DSuspendingagentscandecreasethewettabilityofparticles.Chapter5UnitTesting第1题Forpoorlywater-solubledrugsorthoserequiringprolongeddrugeffectafterinjection,canbepreparedas（）injections.ASterilePowderforInjectionBSuspensionCSolutionDEmulsionESol第2题Intheformulationofinjections,benzylalcoholisaddedtoplaytheroleof().AAntioxidantBAnalgesicCStabilizerDBacteriostaticAgentEChelatingAgent第3题Whichofthefollowingmethodscanbeusedforpyrogentesting?ALimulusAmebocyteLysateTestBRabbitPyrogenTestCBothAandBDFreezingPointDepressionMethodEHotMeltMethod第4题Theisosmoticequivalentofsodiumchloriderefersto().ATheweightofsodiumchlorideisotonicwith100gofdrugBTheweightofsodiumchlorideisotonicwith10gofdrugCTheweightofsodiumchlorideisotonicwith1gofdrugDTheweightofdrugisotonicwith1gofsodiumchlorideETheweightofdrugisotonicwith0.9gofsodiumchloride第5题Thetimeintervalfrompreparationtosterilizationofinfusionsshouldbeminimized,preferablynotexceeding().A4hoursB8hoursC12hoursD16hoursE24hours第6题Themaindifferencebetweentheinspectionitemsofwaterforinjectionanddistilledwateristhatwaterforinjectionmustbetestedfor().AAcidityandAlkalinityBPyrogensCChloridesDMicroorganismsESulfates第7题Whichofthefollowingstatementsaboutthefillingandsealingofinjectionsisincorrect?AFillingandsealingshouldbecarriedoutinthesameroom.Sealingmustbeperformedimmediatelyafterfillingtoavoidcontamination.BThefillingandsealingofsteriledrugsthatcannotbesterilizedinthefinalcontainershouldbeconductedunderaClass10,000cleanroom.CThevolumeinjectedintothecontainershouldbeslightlymorethanthelabeledamounttocompensateforlossesduringadministration.DFillingandsealingoflarge-volume(>50ml)injectionsthatcanbesterilizedinthefinalcontainershouldbeperformedunderaClass100cleanroom.ESealingmethodsarecategorizedintotwotypes:drawsealingandpushsealing.第8题Whichofthefollowingstatementsaboutthecausesofinfusioncontaminationisincorrect?ASeverecontaminationduringtheproductionprocessBIncompletesterilizationCLackofbacteriostaticagentadditionDLooseordefectivestoppersELeakage第9题Whichofthefollowingstatementsaboutthesterilizationofinjectionsisincorrect?AGenerally,1-5mlampulescanbesterilizedbyflowingsteamat100°Cfor30minutes.BSterilizationvalidationshouldbeperformedwithanF₀valuegreaterthan8.CInjectionsofthesameproductfromdifferentbatchescanbesterilizedsimultaneouslyinthesamesterilizationzone.DHeat-stableproductsshouldpreferablybesterilizedat115°Cfor30minutes.EInjectionsmustbesterilizedwithin12hoursfromthetimeofpreparation.第10题ThesterilizationmethodusedforvitaminCinjectionis().AAutoclavingat115°Cfor30minutesBSteamsterilizationat100°Cfor15minutesCSteamsterilizationat100°Cfor30minutesDSteamsterilizationat100°Cfor45minutesESteamsterilizationat100°Cfor60minutes第11题WhichofthefollowingemulsifiersissuitableforO/Wtypeintravenousemulsions?APolysorbate80BRefinedSoybeanLecithinCFattyAcidGlyceridesDEthanolESorbitanFattyAcidEsters第12题Fordrugspronetooxidation,thefollowingmeasurescanbeadoptedduringthepreparationofinjectionstoimprovetheirstability().AAdditionofantioxidantsBAdditionofEDTA-2NaCAdditionofactivatedcarbonfordecolorizationDPurgewithnitrogengasEAvoidusingmetalcontainers第13题Whichofthefollowingisanincorrectdescriptionofthepropertiesofpyrogens?APossessesmoderateheatstabilityandnon-volatilityBHasmoderateheatstabilityandpoorwatersolubilityCIsvolatileDResistanttostrongacids,bases,andoxidizingagentsEWater-solublebutadsorbable第14题Whichofthefollowingmethodscanbeusedtoremovepyrogens?ADryheatsterilizationBMicrofiltrationthroughmembranefiltersCAcid-basetreatmentDAdsorptionmethodEIonexchangemethod第15题Whichofthefollowingstatementsaboutisotonicsolutionsisincorrect?AAnaqueoussolutionwithafreezingpointof-0.52°CisisotonicwithredbloodcellsBAllisotonicsolutionsarealsoisotonicC0.9%sodiumchloridesolutionisbothisotonicandiso-osmoticDIso-osmoticsolutionsareaphysicochemicalconceptEThereisnocorrelationbetweentheosmoticpressureandfreezingpointofasolution第16题Sterilepreparationsarerequiredtobefreeofviablemicroorganisms,whilesterilizedpreparationsmustlimitthetypesandquantitiesofmicrobialcontamination.第17题Autoclavingiscurrentlythemostreliablemoistheatsterilizationmethod,suitableforsterilizingheat-stablepharmaceuticalpreparations.Amongthem,wetsaturatedsteamhasabettersterilizationeffectthansaturatedsteam.第18题Thepreparationofwaterforinjectionbydistillationutilizesthewater-solubilityofpyrogens.第19题Suspensionandemulsioninjectionscanbeusedforbothintramuscularandintravenousadministration.第20题Therelativehumidityinthedispensingroommustbecontrolledabovethecriticalrelativehumidity(CRH)ofthedispensedproducttopreventmoistureabsorptionanddeterioration.Chapter6UnitTesting第1题Increasingtheparticlesizeofdrugscanenhancethedissolutionrateofpoorlysolubledrugsinsoliddosageforms.（)第2题Whenmixingcomponentswithsignificantdifferencesindensity,stratificationmayoccur.（）第3题Wetgranulationtablettingaremainlyusedforthepreparationoftabletsofdrugsthatareheat-sensitiveandhighlysoluble.（）第4题Thethreeessentialconditionsfortabletpreparationarefluidity,compressibilityandgooddisintegrationproperties.（）第5题Thecompressibilityoftheparticlesisthemainfactoraffectingthevariationintabletweight.（)第6题Thevolumeofthe5emptycapsulesislargerthanthatofthe2ndemptycapsule.（）第7题Currently,themostcommonlyusedfilm-formingmaterialforpreparingfilmsinChinaisthenaturalpolymerPVA.（）第8题Whenpreparingpowdersfromtwowater-solublepowderswithCRHvaluesof82%and71%respectively,thehumidityoftheproductionandstorageenvironmentforthemixtureshouldbecontrolledat()ALessthan82%BLessthan76%CLessthan71%DMorethan58%ELessthan58%第9题Thetabletsthatcanavoidthefirst-passeffectoftheliverare()AControlled-releasetabletsBDispersibletabletsCSublingualtabletsDEnteric-coatedtabletsEChewabletablets第10题Thefunctionofthediluentinthetabletis()AReducingthedifferenceintabletweightBIncreasingtheadhesiveforcebetweenmaterialsCInducingtheviscosityofmaterialsDIncreasetheweightandvolumeoftabletsEWaterabsorptionandexpansion,withadisintegratingeffect第11题Themainpurposeofwetgranulationtablettingistoimprove()ADissolutionandsolubilityBCompressibilityandliquidityCCompressibilityandstabilityDCompressibleandantiadhesiveEAntiadhesivedisintegrationproperty第12题TheChinesePharmacopoeiastipulatesthatthedisintegrationtimelimitrequirementforsugarcoatedtabletsis()A120minB60minC45minD30minE15min第13题Thereasonsforproducingfragmentsdonotinclude()AUnevenpressuredistributionBCompressiontimeistoolongCThematerialsaretooelastic.DTheamountofadhesiveisinsufficient.EExcessivedryingofmaterials第14题Nitroglycerinisacommonlyusedemergencytreatmentdrugforanginapectoris.Thetypesoftabletsthatshouldbepreparedare()ABuccaltabletBEffervescenttabletCDispersibletabletsDSublingualtabletsEChewabletablets第15题Whichofthefollowingmedicinalexcipientscanbeaddedtotabletsasadisintegrant()AL-HPCBCC-NaCPVPDCMS-NaEPEG第16题HPMChasawiderangeofapplicationsinpharmacyandcanbeusedas()AAdhesivefortabletsBDisintegratingagentfortabletsCExcipientsforsustained-releasetabletsDFilmcoatingmaterialEPlasticizer第17题Thematerialsusedforpreparingtabletsshouldhave()ACompressibilityBFlowabilityCDisintegrationDLubricityESurfaceactivity第18题Whichofthefollowingfactorsaffecttabletformation()AThecompressibilityofdrugsBTheamountofadhesiveCThemoisturecontentoftheparticlesDThesizeofthedieEThemagnitudeofthepressingforceandthedurationofthepressingprocess第19题Themechanismbywhichdisintegrantspromotedisintegrationincludes()ASwellingBThinlayerinsulationeffectCGasproductioneffectDContainingasignificantamountofsolublecomponentsEMoistureinfiltrationandgasproductioneffect第20题Whichofthefollowingstatementsaboutcapsulesiscorrect()ACapsulescanbetakenorallyoradministeredthroughotherroutes(suchastherectumandvagina)BTheshellmaterialofthecapsuleismainlyarabicgumCOilsolutionsofdrugscanbemadeintocapsules,butaqueoussolutionscannotbemadeintocapsulesDThemethodsforpreparingsoftcapsulesincludedropmethod,compressionmethod,andmeltingmethodECapsulesshouldundergodisintegrationtimelimitandfillingquantitydifferenceinspection第21题WhatistheapplicationoftheNoyes-Whitneyequationinpharmaceuticalformulations()AExplaintherelationshipbetweensolubilityandparticlesizeBExplaintheabsorptionpatternofdrugsinthebodyCPredictingthestabilityofdrugformulationsDUsedtoillustratethedissolutionpatternofdrugsinsoliddosageformsChapter7UnitTesting第1题Transdermaldrugdeliverycanexertbothlocalandsystemiceffects.第2题Water-solubledrugshavegreatersolubilityontheskinsurface,thusaremoreeasilyabsorbedtransdermallythanlipid-solubledrugs.第3题Theprocessoftransdermaldrugabsorptionrefersto:ADrugpenetratestheepidermistodeepertissuesBDrugentershairfolliclesandsebaceousglandsCDrugpenetratesthestratumcorneumintoviableepidermisDDrugentersthelymphaticsystemthroughtheskinEDrugpassesthroughtheepidermisintothedermisandisabsorbedintothebloodstreamviacapillaries第4题WhichofthefollowingfactorsdoesNOTaffecttransdermaldrugabsorption?AApplicationsiteonskinBpHofthebaseCStructureofthedrugDConcentrationofabsorptionenhancersEThicknessofthebackinglayer第5题Whichofthefollowingsubstancesgenerallycannotserveastransdermalabsorptionenhancers?ALiquidparaffinBPolysorbate80CEthanolDDimethylsulfoxideEMenthol第6题Themainrate-limitingstepintransdermaldrugabsorptionis:AStratumcorneumabsorptionBDiffusioninviableepidermisCDiffusionindermisDDiffusioninskinappendagesEDiffusioninsubcutaneoustissues第7题Whichofthefollowingstatementsabouttransdermalformulationsisincorrect?ARapiddrugabsorptionBConvenientadministrationCLowbioavailabilityDReduceddosingfrequencyEEliminationorreductionofbloodconcentrationfluctuations第8题Ointmentscanbeclassifiedintosolutiontype,suspensiontype,andemulsiontypebasedondispersionsystems.第9题Thematrixofgelpatchesgenerallyconsistsofhighmolecularweightadhesive(frameworkmaterial),humectants,fillers,crosslinkingagents,etc.第10题Formulationfactorsaffectingtransdermaldrugabsorptioninclude:ADrugconcentrationBAffinitybetweenbaseanddrugCpHofthebaseDTypeofthebaseEViscosityofthebaseChapter8UnitTesting第1题Pulmonarydrugdeliverycanexertbothlocalandsystemiceffects.第2题Ophthalmicdrugdeliveryonlyexertslocaleffectsandcannotexertsystemiceffects.第3题WhichofthefollowingstatementsregardingthecharacteristicsofpulmonarydrugdeliveryisINCORRECT?ADuetothevastalveolarsurfacearea,richcapillarynetwork,andminimaltransportdistance,drugabsorptionafterpulmonaryadministrationisrapid.BAfterpulmonaryadministration,drugscanenterthesystemiccirculationviathehepaticportalsystem.CSuitableforproteinandpolypeptidedrugs.DAbsorbeddrugscandirectlyenterthesystemiccirculation,avoidinghepaticfirst-passeffects.ECanbeusedfortreatinglungdiseasesorforsystemiceffectsviaalveolarabsorption.第4题Whichofthefollowingsubstancescanbeusedasapropellantinaerosols?APropyleneglycolBEthanolCLaurylalcoholDGlycerinEHeptafluoropropane第5题Three-phaseaerosolsystemisgenerally().AAsmallmoleculesolutionsystemBAsuspensionsystemCAsolidsystemDAliquidsystem第6题Asuspensionaerosolis().ATwo-phaseaerosolBThree-phaseaerosolCSprayDDrypowderinhaler(DPI)第7题Whataretheadvantagesofaerosols?ADrugsaresealedinopaquecontainers,lesssusceptibletocontamination.BCanavoiddestructioninthegastrointestinaltractandhepaticfirst-passeffects.CConvenienttouse,especiallysuitableforOTCdrugs.DAerosolshaverelativelylowproductioncosts.第8题Aerosolscandeliverdrugsdirectlytothesiteofaction,distributeuniformly,andactrapidly.第9题Becauseaerosolscandeliverdrugsdirectlytothesiteofaction,distributeuniformly,andactrapidly,theyaresuitableforuseasinhalationaerosolsinpatientswithheartdisease.第10题Drugsabsorbedviathelungscandirectlyenterthesystemiccirculation,thusavoidinghepaticfirst-passeffects.第11题Drugsusedtopreparesuspensionaerosolsshouldbemicronized,andthemoisturecontentshouldbecontrolledbelow0.03%.第12题Amongthefollowingdosageforms,whichoneexertsitstherapeuticeffectthefastest?ASuppositoryBHoneyedpillCSugar-coatedtabletDAerosolECapsule第13题Forarectalsuppositoryintendedforsystemiceffects,theappropriatesiteofadministrationis().AApproximately6cmfromtheanalorifice.BApproximately2cmfromtheanalorifice.CNeartheanus.DNearthesuperiorrectalvein.EApproximately3cmfromtheanalorifice.第14题WhichofthefollowingstatementsregardingsuspensionaerosolsisINCORRECT?AThelowerthesolubilityofthedruginthepropellant,thebetter.BPreparationofsuspensionaerosolsrequirestheadditionofasuitablecosolvent.CAsuspensionaerosolisasystemcomposedofanaqueousdrugsolution,aliquid,andagaseouspropellant.DThedensitiesofthepropellantandthesuspendedsoliddrugshouldbesimilar.ETheparticlesizeofsuspendedparticlesininhalationsuspensionaerosolsshouldbebelow5μm.第15题Drypowderinhalers(DPIs)usespecializedinhalationdevices,andthepatientactivelyinhalestheaerosolizeddrugintothelungs.第16题Ophthalmicointmentsintendedforuseineyesurgeryortraumashouldbesterilizedorpreparedaseptically,andnopreservativesshouldbeadded.Chapter9UnitTesting第1题Oralsustained-releaseformulationsnotonlyimprovepatientcompliancebutalsoalwayshavehigherbioavailability.第2题Osmoticpumptabletsaresimilartoconventionalcoatedtabletsexceptforasmalllaser-drilledholethroughwhichthedrugisreleased.第3题Alloralmembrane-controlledreleasepreparationsreleasedrugsatzero-orderkinetics.第4题Sustained-releaseformulationsfordrugsabsorbedviaactivetransportcanenhanceabsorption.第5题Whichofthefollowingisacharacteristicofsustained-releaseandcontrolled-releaseformulations?AFrequentdosingandpoorpatientcomplianceBReductionoffirst-passeffectinoraladministrationCParticularlysuitableforacutediseasetreatmentDTotaldoseincreasesEMaintainsrelativelyconstantplasmaconcentrationorpharmacologicaleffect,enhancestherapeuticefficacy,andreducessideeffects第6题WhichofthefollowingisNOTaphysicochemicalpropertyaffectingthedesignoforalsustained-releaseandcontrolled-releaseformulations?ADosesizeBpKaCSolubilityDPartitioncoefficientEBiologicalhalf-life第7题Whichofthefollow