国外知名有机化学家

1、国外著名有机化学家简介,化学02班 谢鑫 002429,化学02班 白楠 002432,讲演人,POZITION Director, Harvard Institute of Chemistry Thieme-IUPAC award in synthetic organic chemistry, 1992; Eli Lilly award in biological chemistry, ACS, 1993; Dupont Merck young investigator award of the protein society, 1995; Tetrahedron prize for cre

2、ativity in organic chemistry, 1997; Derek Barton medal, 1999; Alfred Bader award in bioorganic and bioinorganic chemistry, ACS, 2000;,RECEIVED 30 AWARDS BETWEEN 1985-2000,Thieme-IUPAC Award in Synthetic Organic Chemistry,The Thieme-IUPAC Prize is awarded every two years on the occasion of IUPACs Int

3、ernational Conference on Organic Synthesis (ICOS) to a scientist under 40 years of age, whose research has had a major impact on the field of synthetic organic chemistry. The Prize is sponsored jointly by Georg Thieme Verlag, IUPAC, and the Editors of Synthesis, Synlett, Science of Synthesis, and Ho

4、uben-Weyl.,Thieme-IUPAC Prize in Synthetic Oraganic Chemistry,Schreibers Research,Biologists study pathways and networks by perturbing them and observing the result. Whereas these perturbations most often result from mutations in genetic investigations, they can also result from small organic molecu

5、les. Numerous examples exist of small molecules being used to explore immunology, yet these examples have been brought to light generally on a case-by-case basis. Rather than using small molecules on an ad hoc basis, Stuart Schreibers laboratory is attempting to use them in a systematic way, so that

6、 virtually any area of biology can be examined with small molecules.,Beginning in the mid-1980s, Schreiber and his co-workers studied the molecular mechanisms of the immunosuppressive agents cyclosporin（环孢菌素）, FK506 and rapamycin（雷伯酶素）, which led to new insights into two signaling networks central t

7、o hematopoietic cell function. Using a synthetic analog of FK506, they were able to show that these immunosuppressants “bridge” two proteins. Both the complex of cyclosporin （环孢菌素） with its receptor, cyclophilin（亲环蛋白）, and the complex of FK506 with its receptor, FKBP12, bind the same protein, the pr

8、otein phosphatase calcineurin（磷酸酶神经储钙蛋白）. This discovery, together with Gerald Crabtrees discovery of NFAT proteins, now known to be essential for immune function, heart development, and the acquisition of memory in the hippocampus.,Schreibers Research,Combining synthetic organic chemistry and cell

9、biology, Schreiber and co-workers co-discovered the mammalian protein FRAP, the target of the complex between FKBP12 and rapamycin, and unraveled its role as a metabolic sensor and a regulator of cells response to nutrients. FRAP and its yeast orthologs Tor1p/2p are now recognized as the founding me

10、mbers of a family of proteins called the PIK-related kinases (ATM, ATR, DNA-PK), which act as intracellular sensors monitoring a number of different cellular pathways.,Schreibers Research,Papers production and secondary structure examination of beta peptides; the synthesis of oligomers in (R)-3 hydr

11、oxybutyric acid（羟丁酸） and the respective biopolymers as well as their application possibilities; the synthesis of chiral dendrimers（树枝状大分子） and the use of chiral titanates in organic synthesis.,Synthesis, Structural Investigations and Biological Evaluation of Oligomers of Beta-Amino Acids Investigati

12、ons of the Biopolymer PHB and of related Oligo(3-hydroxyalkanoates) Enantioselective Reactions（对映选择性反应）Using Transition Metal Complexes,Seebachs Research,Prof. Dr. Dieter Seebach Laboratory of organic chemistry ETH Hoenggerberg, HCI CH-8093 Zuerich, Switzerland Tel : +41-1-632 2990 Fax: +41-1-632 11

13、44 E-ail :mailto:seebachorg.Chem.ethz.Ch,Connection,David Evans,David Albert Evans was born in Washington D.C. in 1941. He received his A.B. degree from Oberlin College in 1963. He obtained his Ph.D. at the California Institute of Technology in 1967.In that year he joined the faculty at the Universi

14、ty of California, Los Angeles.,David Evans,In 1973 he was promoted to the rank of Full Professor and shortly thereafter returned to Caltech where he remained until 1983. In 1983 he joined the Faculty at Harvard University and in 1990 he was appointed as the Abbott and James Lawrence Professor of Che

15、mistry. In July of 1998 he completed his three-year term as chair of the Harvard Department of Chemistry and Chemical Biology.,Honors And Awards,Professor Evans is a recipient of numerous honors such as the ACS Award for Creative Work in Synthetic Organic Chemistry (1982), and the Arthur C. Cope Sch

16、olar Award (1988), the Yamada Prize (1997), the Tetrahedron Prize (1998), the Robert Robinson Award (1998), the Prelog Medal (1999), and the Arthur C. Cope Award (2000). He was elected into the National Academy of Sciences in 1984, the American Academy of Arts and Sciences in 1988 and the Royal Soci

17、ety of Chemistry in 2001.,He is currently a consultant with Merck Research Laboratories and with Oxford Asymmetry. He has been on the Advisory Boards of The Journal of the American Chemical Society, Tetrahedron, Tetrahedron Letters, and Topics in Stereochemistry. Currently, he is on the Advisory Boa

18、rds of Organic Letters and Current Opinion in Bio-organic Chemistry, London, UK,Honors And Awards,Evans Research,Evans has made fundamental advances in the design of stereoselective reactions and the applications of these reactions to natural products synthesis.,Significant Advances in Reaction Methodology,In the area of synthesis design, Evans was the first to achieve the de novo synthesis of complex natural products through the exclusive use of chiral auxiliaries to control stereochemical relationships. This represented a dramatic depar