总维生素D检测的重要性及临床意义PPT课件.ppt

1,血清总25OH维生素D检测的重要性及临床应用TheImportanceandClinicalApplicationofTotal25OH-D,1,维生素D营养状况的评判标准,2,聊城地区育龄女性VD状况,统计成人共636人VD1026341.35%10VD2031349.21%20VD30375.82%VD30233.62%,3,聊城地区儿童VD状况,儿童统计364人VD10113.02%10VD206517.86%20VD99.1nmol/L)hada62%lowerriskofdevelopingMS.postmenopausalwomenwiththehighesttotalvitaminDintakeswereatsignificantlylowerriskofdevelopingRAafter11yearsoffollow-upthanthosewiththelowestintakes,2019/12/16,8,多发性硬化症与纬度的关系,PeoplelivingclosertotheequatorareatdecreasedriskofdevelopingMSSimilartrends:cancer,hypertension,2019/12/16,9,促进细胞分化、抑制增殖-维生素D降低肿瘤发生率,TheactiveformofvitaminD,1,25-dihydroxyvitaminD,inhibitsproliferationandstimulatesthedifferentiationofcells.HolickMF.VitaminD:importanceinthepreventionofcancers,type1diabetes,heartdisease,andosteoporosis.AmJClinNutr.2004;79(3):362-371.,2019/12/16,10,促进细胞分化、抑制增殖-维生素D降低肿瘤发生率,2019/12/16,11,12,VitDandDisease,Brain：精神分裂症schizophrenia抑郁症depressionLung：哮喘AsthmaCirculation：高血压Hypertension冠心病CHD中风StrokeImmunosystem:I型糖尿病DM多发性硬化症MS风湿性关节炎RH可降低结核、流感活其他感染性疾病的临床症状TBetc.infectiondisease,肿瘤Tumor：乳腺癌(breast)前列腺癌(prostate)结肠癌(colon)卵巢癌(ovary)骨骼与肌肉Musculoskeletone:骨软化(osteomalacia）代谢性骨病(MetabolicBoneDisease)肌无力(myasthenia)孕妇及胎儿、新生儿,12,维生素D:每个人、人生的每个阶段都要关注,2019/12/16,13,2019/12/16,14,15,维生素D检测的临床应用,儿科：佝偻病、骨软化症、儿童骨骼发育不良、骨折、小儿精神抑郁、自闭症，疗效监测、预防维生素D中毒产科:孕期和哺乳期维生素D检测，预防产科并发症和新生儿维生素D缺乏；预防产后骨质疏松症和抑郁症-中华儿科学会推荐：妊娠3个月查25OHD，确定维生素D的补充剂量,15,维生素D营养状况的评判标准维生素D达到什么水平才能受益,2019/12/16,16,2019/12/16,17,18,总结,维生素D缺乏是很普遍的补充维生素D，不仅促进骨健康，且有益全身健康维生素D理想水