降钙素原检测诊断肺结核合并肺部细菌感染的价值

1、降钙素原检测诊断肺结核合并肺部细菌感染的价值降钙素原检测诊断肺结核合并肺部细菌感染的价值1959202102-0179-02Abstract：Objective To analyze the important value of detecting procalcitonin PCT in clinical diagnosis of patients with pulmonary tuberculosis complicated by pulmonary bacterial infection. Methods The clinical data of 112 patients with tu

2、berculosis diagnosed and treated in our hospital from April 2021 to April 2021 were retrospectively analyzed. 69 patients with uncomplicated pulmonary infection were designated as uncombined group， and 43 patients with combined pulmonary infection were designated as combined group. The combined grou

3、p was given antibacterial treatment， which was divided into the control group and the uncontrolled group according to the antibacterial effect. The serum PCT levels before and after the treatment was compared between the combined group and the uncombined group， the control group and the uncontrolled

4、 group.Results The serum PCT in the combined group was higher than that in the non-combined group，the difference was statistically significantP0.05.There was no significant difference in serum PCT between the control group and the uncontrolled group before treatmentP>0.05;After treatment， the ser

5、um PCT in the control group was lower than before the treatment，and the control group was lower than the non-control group，the difference was statistically significantP0.05.The area under the ROC curve of lung infection of 43 patients in the combined group was 0.941， 95%CI： 0.8960.983， and the cutof

6、f was 0.674 g/L， PCT detection sensitivity was 86.04%37/43， specificity was 94.87%37/39.Conclusion The monitoring of serum PCT in patients with pulmonary tuberculosis complicated by pulmonary bacterial infection can help to determine whether it is associated with pulmonary infection and the effect o

7、f antibacterial treatment. 0.05，讨论可比。治疗后根据抗菌效果分为操纵组21例和未操纵组22例。本讨论经过医院伦理委员会批准，患者自愿参与本讨论，并签署知情同意书。1.2方法1.2.1治疗方法 全部患者均接受规律抗结核化疗，化疗方案2HREZ/4HR，养分状态较差者给予静脉养分支持，合并组行痰液及血细菌培育+药敏试验，给予广谱三代头孢类抗菌药抗感染治疗，细菌培育及药敏结果反馈后根据药敏结果给予敏感抗菌药治疗。1.2.2试验室检测 仪器：瑞士生产全自动生化分析仪;标本采集：取全部患者晨起空腹静脉血5 ml，离心10 min，分别血清后送检。PCT接受半定量的胶体金免

8、疫结合法，严格根据PCT定量测定试剂盒说明书进行操作。1.3观看指标 比较合并组与未合并组血清PCT水平;操纵组和未操纵组治疗前后血清PCT水平。肺部感染操纵：抗感染治疗7 d后体温正常，无反复发热，肺部影像学表现改善或无进展或痰液、血液标本菌培育阴性则为肺部感染操纵;抗感染治疗后仍有反复发热、肺部影像学显示进展，则为肺部感染未操纵。1.4统计学方法 使用SPSS 24.0统计软件进行分析，计量资料接受x±s表示，两组间比较接受t检验，计数资料接受n和%表示，两组间比较接受？字2检验，P0.05;治疗后操纵组血清PCT低于治疗前，且操纵组低于未操纵组P<0.05，说明抗感染治疗有效患者治疗后PCT水平下降，未掌握组患者PCT水平无明显改变，进一步提示PCT水平改变在肺结核合并肺部感染治疗中可较早预报抗菌药物治疗疗效。肺部细菌感染R0C曲线下面积为0.941，95%CI：0.8960.983，临界值为0.674 g/L，PCT检测敏感度为86.04%37/43，特异度94.87%37/39，PCT判定肺结核合并肺部感染的最正确临床临界参考值为0.674 g/