S119-8 - Influenza Virus 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemES119-8Cat. No.: HY-112543CAS No.: 443639-96-1分式: CHNO分量: 344.45作靶点: Influenza Virus作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (435.48 mM)* means soluble, b

2、ut saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9032 mL 14.5159 mL 29.0318 mL5 mM 0.5806 mL 2.9032 mL 5.8064 mL10 mM 0.2903 mL 1.4516 mL 2.9032 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 S119-8A 型和 B 型流感病毒的谱抑制剂。IC50 & Target Influenza A and B 1体外研

3、究S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improvedcalculated physical properties, while maintaining significant potency (IC50=1.43 M) at non-toxic1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE(CC50=66.10 M) concentrations, albeit somewhat higher (7-fo

4、ld) than that of the parent S119 againstinfluenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses andan oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus(VSV). S119-8 has increased breadth of inh

5、ibition against influenza A and B viruses accompanied by only asmall loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of6.05 M. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 M 1.REFERENCES1. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb9;4(2):146-157.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379