AT-007-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAT-007Cat. No.: HY-129586CAS No.: 2170729-29-8分式: CHFNOS分量: 425.4作靶点: Aldose Reductase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 35.71 mg/mL (83.94 mM; Ne

2、ed ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3507 mL 11.7536 mL 23.5073 mL5 mM 0.4701 mL 2.3507 mL 4.7015 mL10 mM 0.2351 mL 1.1754 mL 2.3507 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存

3、条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.25 mg/mL (5.29 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.25 mg/mL (5.29 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 AT-007种服活性的，于治

4、疗半乳糖症的中枢神经系统 (CNS) 渗透性醛糖还原酶抑制剂， 其 IC50 值为 100 pM。在 GALT 缺失中，AT-007 降低了有毒的半乳糖醇平并预防了疾病并发症。IC50 & Target IC50: 100 pM (Aldose Reductase) 2体内研究 AT-007 significantly reduces galactitol levels in GALT null rats in all traget tissues ( liver, brain and plasma),and does not increase galactose or Gal-1P leve

5、ls 2.REFERENCES1. Maeve Conneighton, et al. Applied Therapeutics Announces Initiation of Phase 1/2 Study of AT-007 in Galactosemia.2. UNITED STATES SECURITIES AND EXCHANGE COMMISSION. APPLIED THERAPEUTICS, INC.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589