TLR4-IN-C34-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemETLR4-IN-C34Cat.No.:HY-107575CASNo.:40592-88-9分⼦式:C₁₇H₂₇NO₉分⼦量:389.4作⽤靶点:Toll-likeReceptor(TLR)作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(642.01mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5681mL12.8403mL25.6805mL5mM0.5136mL2.5681mL5.1361mL10mM0.2568mL1.2840mL2.5681mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥6.25mg/mL(16.05mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥6.25mg/mL(16.05mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(16.05mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性TLR4-IN-C34具有⼝服活性的TLR4抑制剂，可改内毒素⾎症和坏死性⼩肠结肠炎模型的全⾝炎症。体内研究TLR4-IN-C34(C34,1mg/kg,orallydaily)couldattenuateNECseverityanddemonstratesamarkedpreservationoftheintestinalmucosa[1].AnimalModel:ExperimentalNECinducedin7-8dayoldmice[1].Dosage:1mg/kg.Administration:Orallyeverymorning.Result:Attenuatedintestinalinflammation.REFERENCES[1].NealMD,etal.DiscoveryandvalidationofanewclassofsmallmoleculeToll-likereceptor4(TLR4)inhibitors.PLoSOne.2013Jun12;8(6):e65779.[2].WipfP,etal.Synthesisofanti-inflammatoryα-andβ-linkedacetamidopyranosidesasinhibitorsoftoll-likereceptor4(TLR4).TetrahedronLett.2015Jun3;56(23):3097-3100.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3