Cinobufagin-Cinobufagine-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECinobufaginCat. No.: HY-N0421CAS No.: 470-37-1Synonyms: Cinobufagine分式: CHO分量: 442.54作靶点: Autophagy作通路: Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 43 mg/mL (97.17 mM)* means s

2、oluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2597 mL 11.2984 mL 22.5968 mL5 mM 0.4519 mL 2.2597 mL 4.5194 mL10 mM 0.2260 mL 1.1298 mL 2.2597 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 华蟾酥毒(Cinobufagin) 种天然化合物，具有抗肿瘤的功效，临床上对其研究泛，尤其 在肝癌的研

3、究。REFERENCES1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE1. Zhang G, et al. Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall celllung cancer cells. Oncotarget. 2016 Mar 3.2. Yu Y, et al. Immunomodulatory Effects of Cinobufagin on M

4、urine Lymphocytes and Macrophages. Evid Based Complement AlternatMed. 2015;2015:835263.3. Baek SH, et al. Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signalingpathway. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):265-73.4. Jiun-Yih Yeh,

5、et al. Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells.The ProstateVolume 54, Issue 2, pages 112124, 1 February 20035. Yu CH, et al. Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human p

6、rostate cancercells. Cancer Science, 2008, 99 (12): 2467-24766. Peng Bei, et al. Progress in study on basic and clinical application in treating liver cancer by Cinobufagin Injection. Drug EvaluationResearch, 2011-01McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-82