雨课堂学堂在线学堂云《生殖医学研究热点（Hot Research Topics in Reproductive Medicine）(山东)》单元测试考核答案

第1题whichstainingistodetectSpermDNAintegrityACD45/CD53BSYBR14/PICAcridineorangeDJC-1第2题decidualNKcellshighlyexpressACD49aBCD19CCD117DEOMES正确答案：AD第3题thespermatogoniaproliferateanddifferentiateintotheprimaryspermatocytes,whichcontain____amountofDNAA2-foldB3-foldC4-foldD6-fold第4题The____ofthefluorescentsignalreflectsthelevelofexpressionAamountBintensityCvolumeDheight第5题FlowcytometryiscapableofmeasuringARNAcontentBDNAcontentCproteincontentDEnzymeactivity正确答案：ABCD第6题ApoptosiscorrelateswithACaspaseactivityBDNAcontentCCyclinexpressionDHistoneH3phosphorylation第7题whichcanbedetectedinearlyapoptosis?APhosphatidylSerineexposureBimpermeablemembraneCDNAfragmentationDdoublepositiveforAnnexinVand7AADdyes正确答案：AB第8题TheforwardscattercorrelateswithAcellsizeBthegranularityofthecellCinternalcomplexityofthecellDcell-surfacearea正确答案：AD第9题Whatdoesthescatteredlightsignalofflowcytometryinclude?AFluorescencesignalBForward-scatteredlightCSide-scatteredlightDBackward-scatteredlight正确答案：BC第10题WhenearlyapoptoticcellsarestainedwithAnnexinVand7AADAdoublenegativeBsinglepositiveforAnnexinVCsinglepositivefor7AADDdoublepositive第11题WhenviablecellsarestainedwithAnnexinVand7AADAdoublenegativeBsinglepositiveforAnnexinVCsinglepositivefor7AADDdoublepositive第12题WhennecroticcellsarestainedwithAnnexinVand7AADAdoublenegativeBsinglepositiveforAnnexinVCsinglepositivefor7AADDdoublepositive第13题CellproliferationandcellcycleBrdUorEDUcanbeincorporatedintoreplicatedDNAduringtheAG1phaseBSphaseCG2phaseDMphase第14题whichstainingistoanalyzesemenleukocytecontentACD45/CD53BSYBR14/PICAcridineorangeDJC-1第1题Toreducetheeffectofvarioushormonesandgrowthfactorsintheserumonthefunctionofgranulosacells,charcoal/dextran-strippedfetalbovineserumcanbeusedforgranulosacellculture.第2题Invitroculturedgranulosacellscanbepassagedaftergrowthandproliferation,andcanbelong-termculturedinvitro.第3题Duringfolliculardevelopment,granulosacellsundergodynamicchanges,andtheirproliferation,differentiation,andmetabolismarecloselyrelatedtothestagesoffolliculardevelopment.第4题Withoutfactorsderivedfromoocytesandthecal/interstitialcellsandtheregulationoftheintra-ovarianmicroenvironment,granulosacellsculturedinvitrohaveatendencytospontaneouslyluteinize.Therefore,alongdurationisnotappropriateforgranulosacellculture.第5题第6题TheeffectsofFSHongranulosacellinclude().APromotegranulosacellproliferationanddifferentiationBPromoteestrogensynthesisCPromoteprogestinsynthesisDRegulationofLHRexpression正确答案：ABD第7题Applicationsofgranulosacellcultureinclude().AStudyofproliferation,apoptosis,differentiationofgranulosacellsBStudyofestrogensynthesisofgranulosacellsCStudyofestrogensecretionfromgranulosacellsDStudyofmetabolismofgranulosacells正确答案：ABCD第8题Invitroculturecanbeappliedtogranulosacellsatdifferentdevelopmentalstages,andthegeneralmethodsforobtaininggranulosacellsinclude().ADigestionaftermechanicalseparationofpre-antralfolliclesBPuncturingmouseovariesafterPMSGinjectionCIsolationofgranulosacellsaftersuperovulationinmiceDHumangranulosacellsobtainedfromoocyteretrievalduringassistedreproductionprocess正确答案：ABD第9题Forskolin,whichisanactivatoroftheadenylatecyclase,canbeaddedalonetomimictheeffectsofLH.第10题KGNcellsarethehumanlutealgranulosacelllineimmortalizedbytransfectionwithSV40largeTantigen.第11题Ovariesofmiceinjectedwithpregnanthorseserumgonadotropinshouldbetakenat()toreleasegranulosacellsbypuncturingmouseovaries.A12hoursB12-24hoursC24-48hoursD48-72hours第12题Limitationsofinvitrocultureofgranulosacellsdonotinclude().ATheshortdurationofinvitrocultureBCannotbeculturedforpassagingCWithoutthecyclicregulationofgonadotropinsDWithouttheregulationfromoocytesandthecal/interstitialcells第13题Duringgranulosacellculture,itissometimesnecessarytoapplyphenolred-freemediumdueto().APhenolredhasestrogen-likeeffectsBPhenolredhasprogestin-likeeffectsCPhenolredhastestosterone-likeeffectsDPhenolredaffectstheproliferationofgranulosacells第14题Whenstudyingthefunctionofestrogensynthesisingranulosacells,__isusuallyaddedtotheculturemedium.ALHBFSHCProgestinDTestosteroneExercises第1题Avoidexcessmediuminsidethecultureinsertduringincubation.第2题Currentinvitroovarianculturetechniqueshavebeenabletofullyreflectthephysiologicalprocessesoffolliculardevelopmentinvivo.第3题Undertheregulationofgonadotropin-releasinghormonesecretedbythepituitarygland,theovaryexhibitscyclicchangesinfolliclerecruitment,growth,maturation,ovulation,andcorpusluteumformation.第4题Invitrocultureofovariesatdifferentstagescanbeusedtostudy().AOvariandevelopmentBPrimordialfollicleassemblyandformationCLatefolliculardevelopmentDHormonesynthesisandsecretion正确答案：ABD第5题Culturingof()canbeusedtostudyprimordialfollicleactivationprocess.AEmbryonicmouseovaryBPD3-4mouseovaryCAdultmouseovaryDHumanovariantissue正确答案：BCD第6题Ovarianculturecanbeusedtostudy().APrimordialfollicleactivationBEarlyovariandevelopmentCGermcelldevelopmentDFemalereproductivetoxicity正确答案：ABCD第7题Ovaryisanimportantfemalereproductiveendocrineorgan,withtwomainfunctionsofproducingoocytesandsecretingfemalehormones.第8题Becauseofthesmallsize,suspensioncultureofintactovariescanbeappliedtotheovariesofmicefromembryonicday13.5to4daysafterparturition.第9题Ovariesfrommicecanbeculturedintactduetotheirsmallsize.Incontrast,humanovariantissueneedstobepreparedintosectionsordividedintosmallerpiecesduetoitslargesize.第10题Theovariesshouldbeplacedincloseproximitytoeachotherwhenplacedinthecellcultureinserttofacilitatehandling.第11题Theadultovarycontainsfolliclesatdifferentstagesofdevelopment,withthe()beingtheearlieststage.APrimaryfolliclesBSecondaryfolliclesCPrimordialfolliclesDAntralfollicles第12题Thedurationofinvitroovariancultureistooshorttocompletethewholeprocessoffolliculardevelopment,especiallyinpostnatalmicethefolliclescannotdevelopbeyondthe()stage.APrimaryfolliclesBSecondaryfolliclesCAntralfolliclesDPreovulatoryfollicles第13题Thelongestculturedwholeovarycansurviveforabout()weeks.A1B2C3D4第14题Thecultureconditionsforovarianinvitroculturewere()CO2and37°Ccellincubator.A0.01B0.03C0.05D0.07第15题()canbeobservedinPD4miceovariesafter2weeksculturedinvitro.APrimordialfolliclesBPrimaryfolliclesCSecondaryfolliclesDAntralfollicles正确答案：ABCExercises第1题PCOSisasinglegenegeneticdisease第2题THADA

knockoutin

Drosophila

leadstoobesityaccompaniedbyhyperphagia,reducedthermogenesis,andanincreasein

lipidstorage

mostlyinthefatbody.Interestingly,Themalephenotypewasmorepronounced.第3题WhichofthefollowingaretheoldnamesofPCOSAStein-LeventhalsyndromeBPCODCPCODPCOMEStein-Leventhaldisease正确答案：AB第4题WhichofthefollowingarePCOScomplicationsAInfertilityBObesityCMetabolicsyndromeDGDMEGestationalhypertension正确答案：ABCDE第5题WhichPCOSsuscepticalgenesinChenzijiang’sGWAShavebeenconfirmedinEuropeanandAmericanpopulationsAFSHRBLHCGRCTHADADDENND1AEC9orf3正确答案：CD第6题WhichofthefollowingarePCOSsusceptibilitygenesfoundinGWASAFSHRBLHCGRCTHADADDENND1AEC9orf3正确答案：ABCDE第7题Thename"polycysticovarysyndrome"onlyrepresentsthemorphologicalcharacteristicsofpolycysticovaries,butdoesnotreallycovertheessenceofthisdiseasewithitsvariableclinicalmanifestationsandcomplexpathogenicmechanisms第8题GiventhehighlyheterogeneousnatureofPCOS,whatisthecharacteristicof“reproductivegroup”AlowerLH，lowerSHBG，LowBMI，LowinsulinBHigherLH，HigherSHBG，LowBMI，LowinsulinCLowerLH，LowerSHBG，HigherBMI，Higherinsulin，HigherGlucoseDLowerLH，LowerSHBG，HigherBMI，Lowinsulin，HigherGlucoseELowerLH，LowerSHBG，HigherBMI，Lowinsulin，LowGlucose第9题Female,28yearsold.Notpregnantfor5yearsaftermarriage,withsparsemenstruation,obesityandhairiness.Gynecologicalexamination:noabnormalityisfoundintheuterusandbilateralovariesareslightlylarger.Basalbodytemperaturemonophasic.Thepatient'smostlikelydiagnosisisAPolycysticovarysyndromeBGenitaltuberculosisCAnovulatorydysfunctionuterinebleedingDPrematureovarianfailureEEndometriosis第10题AboutTHADA，whichisthefalsestatementAAssociatedwithBMI、T2DMandMultipleSclerosisBTheencodedprotein,ThyroidAdenoma-AssociatedProteinislikelyinvolvedinthedeathreceptorpathwayandapoptosis.COvereexpressionofTHADA,FliesareObese,Hyperphagic,ReducedEnergyProduction,SensitivetoColdDTHADAisinvolvedinplantscoldacclimationbyregulatingmTORactivityETHADAregulationmightprovidenewtherapeutictargetsforthetreatmentofreproductiveandmetabolicdiaseaselikePCOS第11题InMendelianRandomizationStudy,whichisthecausaleffectonPCOS?AIncreaseBMIBIncreaseAMHCIncreaseDHEASDIncreaseDiastolicBPEIncreaseSystolicBP第12题AboutPCOS，whichstatementiwrong？APCOSismorethanareproductivedisorder.Itaffectswomen‘sphysicalandmentalhealththroughouttheirlives.BThename"polycysticovarysyndrome"onlyrepresentsthemorphologicalcharacteristicsofpolycysticovaries,butdoesnotreallycovertheessenceofthisdiseasewithitsvariableclinicalmanifestationsandcomplexpathogenicmechanisms.CPCOSisadiseasecausedbyaninteractionbetweengeneticsandtheenvironment.TherearenumerousenvironmentalfactorscancontributetothedevelopmentofPCOS.DPCOShasafamilialaggregationwithaheritabilityofabout72%,andenviromentisthemaincausativefactor第13题What'sthePCOSRotterdamCriteriaAAnovulationoroligo-ovulation,clinicaland/orbiochemicalhyperandrogenism,BClinicaland/orbiochemicalhyperandrogenismandpolycysticovarianmorphology(PCOM)seenonultrasoundCAnovulationoroligo-ovulation,clinicaland/orbiochemicalhyperandrogenism,andpolycysticovarianmorphology(PCOM)seenonultrasoundDRequiringtwoofthreefeatures:anovulationoroligo-ovulation,clinicaland/orbiochemicalhyperandrogenism,andpolycysticovarianmorphology(PCOM)seenonultrasoundERequiringtwoofthreefeatures:anovulationoroligo-ovulation,clinicaland/orbiochemicalhyperandrogenism,andpolycysticovarianmorphology(PCOM)seenonultrasound，exclusionoftheotherpossiblerelateddisorders正确答案：E第14题WhichisthefalsestatementAARisonlyexpressedinovaryandisakeymoleculeinmediatingthebiologicaleffectsofandrogensBBoththeSNP(rs6152)anditsN-terminal(CAG)nintheARgeneregionweresignificantlyassociatedwithPCOSCARknockoutmiceshowhyperandrogenism,increasedfollicularatresia,andovulationdysfunctionDItisregulatedbyFSHandinvolvedinfollicledevelopmentEARisalsoinvolvedinbothreproductiveprocessesandmetabolicregulation,likeadipocytesize,fattyliverandsoon.第15题Abouttheenviromentalfactors，whichisthefalsestatementAVPAcommonlyaffectedmanysteroidmetabolismrelatedgenesBDecreasedserumlevelsofbisphenolAhavebeenfoundinwomenwithpolycysticovarysyndrome(PCOS)CCommonadverseeffectsofVPAarePCOS-likechanges(hyperandrogenism,menstrualcyclechanges,PCOMDSeveralstudiesindicatedthatwomenwithPCOShavelowerlevelsofvitaminDEThereare3kindofsportstype,power\endurance\technical.Interestingly,PCOSwasleastinthepowergroup第16题TheclinicmanifestationofPCOSdoesn'tincludeAOligo/amenorrheaBHyperandrogenismCIrregularuterinebleedingDPCOonultrosoundEAnemia正确答案：E第17题ThemostcommonendocrineandreproductivediseasesinwomenofchildbearingageisAPolycysticovarysyndromeBGenitaltuberculosisCAnovulatorydysfunctionuterinebleedingDPrematureovarianfailureEEndometriosis第18题What'sthecentraleventinthedevelopmentandpathogenesisofPCOSinAESAAndrogenexcessBAmenorrheaCOligomenorrheaDPCOMEIrregularuterinebleeding第19题WhichofthefollowingstatementsiswrongAIn2011,ChinesePCOSdiagnosticstandardborn:Oligo/amenorrheaand/orirregularuterinebleedingaretheprerequisitesitems.BOligomenorrheaiscentraltothepresentationinadolescents,whereasthereisnoconsistentphenotypeinpostmenopausalwomen.CGC–MSorLC–MSarerecommendedasgoldstandardmethodsforevaluatingsteroidhormonesDFreetestosteronelevelsaremoresensitivethanthemeasurementoftotaltestosteroneforestablishingtheexistenceofandrogenexcessandshouldbeideallydeterminedthroughequilibriumdialysistechniques.ECalculatedfreetestosterone,freeandrogenindexorcalculatedbioavailabletestosteroneshouldbeusedtoassessbiochemicalhyperandrogenisminthediagnosisofPCOS.第20题WhichistheNIHcriteriaforPCOSAMeetingtwoofthree：anovulationoroligo-ovulation,clinicaland/orbiochemicalhyperandrogenism,andpolycysticovarianmorphology(PCOM)seenonultrasoundBandrogenexcessshouldbepresentandaccompaniedbyoligomenorrheaorPCOMorbothofthemChyperandrogenismiscentraltothepresentationinadolescents,whereasthereisnoconsistentphenotypeinpostmenopausalwomenDpresenceofclinicaland/orbiochemicalhyperandrogenismandoligo/amenorrheaanovulationEbasedonRotterdamstandards,Calculatedfreetestosterone,freeandrogenindexorcalculatedbioavailabletestosteroneshouldbeusedtoassessbiochemicalhyperandrogenisminthediagnosisofPCOSExercises第1题HTR8cellsarewidelyusedforstudyingtheinvasionandproliferationbehaviorsoftrophoblasts第2题Humantrophoblaststemcellscanbedifferentiatedintobothsyncytiotrophoblastsandextravilloustrophoblasts.第3题Thechoriocarcinomacelllines,BeWo,JEG-3andJAR,arelowlymalignant,containnormalnumbersofchromosomes.第4题Primaryhumantrophoblastcellsareisolatedfromthefirst-trimesterofplacenta.第5题Theshallowtrophoblastinvasioncanleadtothereleaseofsolubleunfavorablefactorsinthematernalcirculationthatresultinsystematicendothelialdysfunctionandclinicalmanifestationsofpreeclampsia.第6题Bytheendof3rdweek,embryonicbloodvesselshavebeguntoformintheextraembryonicmesodermofthesecondarychorionicvilli.第7题Theshallowtrophoblastinvasionisresponsibleforsubsequent()AdecreasedHCGsecretionBimpropermaternalspiralarteryremodelingCincreasedplacentalbloodflowDpoorplacentation正确答案：BD第8题Themouseplacentahasquitedifferentstructureandcelltypes,andinparticular,it’squitedifferentintermsofearlydevelopmentalpathwaysthatregulateitsgrowth.第9题Themouseisaperfectmodelforstudyinghumanplacentaldevelopment.第10题BeWocellsareusuallyusedforinvestigatingthedifferentiationofcytotrohoblaststosyncytiotrophoblasts.第11题Investigationtoolsofhumanearlyplacentationinvitroincluding()AcellmodelsBPrimaryhumantrophoblastcellsCvillousexplantsDorganoid正确答案：ABCD第12题Normalumbilicalcordcontains()A1umbilicalartery,2umbilicalveinsB2umbilicalarteries,1umbilicalveinC1umbilicalartery,1umbilicalveinD2umbilicalarteries,2umbilicalveins第13题WhichcellsexpressHLA-Gontheirsurfaceandareinvasive?AsyncytiotrophoblastcellBcytotrophoblastsCextravilloustrophoblastsDInnercellmass第14题Themostcommonneonatalcomplicationsofpreeclampsiais()AintrauterinegrowthrestrictionBeclampsiaCoedemaDabruptioplacentaeExercises1第1题Theoutcomeincohortstudyisallaboutmorbidity第2题Cohortstudyisobservationalresearch第3题Acohortisagroupofpeoplewhoshareacommonexperienceorstate第4题Exposurefactorissuspectedpathogenicfactororprotectivefactor第5题Dependingonthetimeinwhichtheyenterthecohortandthetimeinwhichtheyendtheirobservation,thecohortcanalsobedividedintoARetrospectivecohortBProspectivecohortCRetro-prospectivecohortDbothofthem第6题WhichfactorisnotneccesarryincohortstudydesigningAexposurefactorBoutcomeCbiasDpopulation第7题ThecontrolstrategiesofinformationbiasincludeAParticipantswithgoodcomplianceBimprovingqualitycontrolCClearstandards,strictimplementationDRegularsamplingreview正确答案：BCD第8题WhatdosetheC.E.OtriangleinvolveAconfoundingBcausesCexposureDoutcome正确答案：ACD第9题CommonbiasincohortstudyincludeAselectionbiasBcollectionbiasCMisclassificationbiasDConfoundingbias正确答案：ACD第10题WhatcanwedotodecreaseconfoundingbiasAStratificationanalysisBImprovecomparabilityCRegularsamplingreviewDStrictselectionofparticipants正确答案：AB第11题Theparticipantsinacohortstudyincludesexposedpopulationandnon-exposedpopulation第12题losttofollow-upinacohortstudycauseselectionbias第13题Inacohortstudy,thestarttimepointisbeforeexplosure,it'sprospectivecohort第14题TheDutchfaminecohortisabithcohort第15题WhichofthemhasthehighestlevelofclinicalevidenceArandomizedcontroltrialsBcohortstudiesCcase-controlledstudiesDcaseseries第16题InwhichcohortcanindividualsleaveorbeaddedovertimeAopencohortBfixedcohortCbothofthemDnoneofthemExercises2第1题Cohortstudycannotstudyforprognosticprediction,treatmentandindividualizedtherapy第2题Understandingaboutbaselineinformationtodevelopandimplementcontrol,preventionandhealthpromotionplancometruebycohortstudy第3题Cohortstudyhasthedoubleadvantageofunderstandingaboutnaturalhistoryoftheoutcomeandanalyzingtherelationshipbetweenonecauseandmanyoutcomes第4题Cohortstudycannotexplorenaturalhistoryofdisease第5题Cohortstudycanobtaintheincidenceofoutcomeinexposedgroupandcontrolgroupdirectly,calculatingRR,ARandotherindicatorsreflectingdiseaseriskintensitydirectly第6题Cohortstudycantesthypothesisfromdiseasetocause第7题Cohortstudycancompleteandreliabledatawithoutrecallbias第8题Largesamplesizesincohortstudycanleadtostableresults第9题Aretrospectivecohortstudy:GestationalcarriersbenefitsLBRsforsomepatientsseekingART,especiallyforuterine-factorinfertilityillustratesthatcohortstudycanATesthypothesisofetiologyBEvaluatetheeffectoftreatment/preventionCExplorephysiologicalprocess/naturalhistoryofdiseaseDMonitorthesafety/efficacyofdrug/technology第10题AstudyshowedthatART-associatedepigeneticvariationatbirthlargelyresolvesbyadulthoodillustratesthatcohortstudyATesthypothesisofetiologyBEvaluatetheeffectoftreatment/preventionCExplorephysiologicalprocess/naturalhistoryofdiseaseDMonitorthesafety/efficacyofdrug/technology第11题AstudyconfirmedthatOffspringconceivedbyfrozenETweresimilartothoseinNCchildrenillustratesthatcohortstudyATesthypothesisofetiologyBEvaluatetheeffectoftreatment/preventionCExplorephysiologicalprocess/naturalhistoryofdiseaseDMonitorthesafety/efficacyofdrug/technology第12题CohortstudycanbeusedtomonitorAthesafetyofdrugBthesafetyoftechnologyCtheefficacyofdrugDtheefficacyoftechnology正确答案：ABCD第13题OneoftheobjectiveofCohortStudyistestinghypothesisofetiology第14题Theeffectofpreventioncanbeevaluatedbycohortstudy第15题AprospectivecohortstudyprovedthatMDADduringthefirsttrimesterincreasethriskoflowbirthweightinIVFoffspringillustratesthatcohortstudycanATesthypothesisofetiologyBEvaluatetheeffectoftreatment/preventionCExplorephysiologicalprocess/naturalhistoryofdiseaseDMonitorthesafety/efficacyofdrug/technologyExercises第1题Theprevalenceofendometrialpolypsininfertilepatientswithendometriosisislow,andpolypsareoftencomplicatedwithsimplehyperplasia.第2题WhichwomenshouldhaveroutinehysteroscopybeforeIVF?ATheresultsofthevaginalultrasoundwereabnormal.BRSACOHSSDRIFEPCOS正确答案：ABD第3题Continuousproximaltubalobstructionbysalpingography?AAnatomicstructuralobstructionBTubalpolypCUterinefibroidsDTubaladhesionETubalpregnancy正确答案：ABCD第4题Causesoffemaleinfertility?ATubalobstructionBEndometriosisCHistoryofectopicpregnancyDThereisnoovulationEUterinefibroids正确答案：ABE第5题Whatcausesmaleinfertility?ANospermBLessspermCTeratospermiaDMalesexualdysfunctionEProstatichyperplasia正确答案：ABCD第6题第7题Endometriosisinfertilitypatientsoftencombinedendometrialpolyps?ATypicalhyperplasiaBAtypicalhyperplasiaCComplexproliferationDSimplehyperplasiaECompoundproliferation第8题WhatintrauterinemyomadiametersignificantlyreducesdeliveryratesinIVF/ICSIpatients?A2cmB2.35cmC2.85cmD3.45cmE3.75cm第9题Istheharmfuleffectoftype3fibroidsofatleastwhatdiameteronwomensignificant?A1cmB2cmC3cmD4cmE5cm第10题WhatistheoptimalwaitingtimeforfreshETafterhysteroscopicadhesiolysis?A60-90daysB90-180daysC180-240daysD240days-360daysE1-2years第11题Toavoidmiscarriage,pregnantwomenwithahistoryofTCRAwhoundergoembryotransferduringivftreatmentarecarefullymonitored第12题Surgeryforectopictubalpregnancyisoneofthecausesofmidwayobstruction第13题WomenwithahistoryofEPhaveanincreasedriskofrecurrentEPafterivf第14题Laparoscopicsurgerywithheterochromictubeandhysteroscopictuballigationisthemostcommonsurgicaltreatmentforproximaltubalobstruction.第15题Whatpercentageofinfertilitycausesarefemalefactors?A0.2B0.3C0.4D0.5E0.6第16题Whatarethemostcommoncausesofinfertilityinwomen?ACervicalfactorBUterinefactorsCTubalfactorDEndocrinefactorEImmunefactors第17题WHOdefinesinfertilityasapairofspousesWHOhaveanormalsexuallife,withoutcontraceptionafterhowmanyyearsisstillnotpregnantcalledinfertility?A1yearB2yearsC3yearsD4yearsE5yearsExercises第1题Commercialoocytedonationisillegal第2题Reproductiveagingcanbestopped第3题Asthesizeoftheoocytepooldiminishes,higherlevelsofFSHisneededtopromotefollicledevelopment第4题Theoptimalageforchildbearingisbetween5and15years第5题AMHandAFCarethemostsensitivepredictorofovarianreserve第6题InhibinBisproducedby()inresponsetoFSHstimulationAsmallantralfolliclesBpre-antralfolliclesCprimordialfolliclesDoocytes第7题Increasedmaternalagealsoassociatewithalotofobstetriccomplications,includingA

gestationaldiabetesBplacentapraeviaCplacentaabruptionDhypertensionEcaesareansection正确答案：ABCDE第8题clinicalbiochemicalpredictorofovarianreserve?（）AFSHBAMHCInhibinBDLHEGH正确答案：ABC第9题WhatistheClinicalmeasuresofOocytequality?（）AageBAFCCIVFoutcomeDFSHEAMH正确答案：ABC第10题ThestrategiesoffertilitypreservationincludeAembryofreezingBoocytecryopreservationCovariantissuecryopreservationDautotransplantation正确答案：ABCD第11题TheaverageageofmenopauseonsetinChinesefemalesis48第12题Theovarianageingischaracterizebydeclineinoocyte‘quality’notquantity第13题AntralfolliclecountphysiologicallydeclinealongwithaginganddirectlyreflecttheIVFoocyteyield第14题ThereproductiveagingbeginsafterwomenreachtheirA

Afterwomenreachtheirmid-thirtiesBAfterwomenreachtheirmid-twentiesCAbout50yearsofageDAbout45yearsofageE48yearsold第15题ReproductiveagingnotdemonstratewithA

infertilityB

increasedrateofmiscarriageC

BirthdefectsDIncreasedClinicalpregnancyrate(CPR)第16题FSHisagonadotropinstimulatesthematurationofAprimordialfolliclesBsecondaryfolliclesCantralfolliclesDoocytesExercises第1题ThestageoffollicledevelopmentarePGC,oogonia,primaryoocyte,primordialfollicle,primaryfollicle,secondaryfollicle,antralfollicle,graafianfollicle.第2题Theprocessoffollicledevelopmentinvolvesmitosisandmeiosis.第3题WhatarethefindingsofcandidategeneapproachinPOI？__.AEstablishedthefundamentalfieldofPOIgenetics.BBasedongeneswithknownfunctiononfolliculogenesis,orwithPOIphenotypesinanimalmodels.CHeterozygousvariantsaremorecommon.DMutationratesvarysignificantlyamongdifferentethnicities.正确答案：ABCD第4题WhichofthefollowinggenesarerelatedwithmRNAtranscriptionandtranslation.AMRPS22BPOLR2CCeIF4ENIF1DKHDRBS1正确答案：ABCD第5题Geneticstudiescanprecedefullclinicalphenotypemanifestation,anditissignificantindiseasediagnosisandlong-termfollowup.第6题Pathogenicheterozygousmutationsonlyidentifiedinpatientswithprimaryamenorrhea.第7题IdentificationofindividualswithPOIriskremainsachallenge.Targetedpanelsofhotspotmutationsand/orcausativegenes,willaddimportantvalueinriskprediction,diagnosis,andearlierintervention.第8题AmongPOIcausativegenes,candidategeneapproachdoesidentifycausativegenesresponsiblefor__.AFolliculardevelopmentBDNAdamagerepairCHomologousrecombinationDMeiosis第9题__,__and__arepleiotropicgenes.ASALL4BMRPS22CBRCA2DFSHR正确答案：ABC第10题For__gene,severemutationswillcompromisemitochondrialenergyproductionandcausesyndromicphenotypes;whereasmildmutationsonlyaffectprimarilyinreproductivesystem.ASALL4BMRPS22CBRCA2DFSHR第11题AwidespectrumofetiologiescouldcausePOI,including__.AGenetic.BAutoimmune.CInfectious.DIatrogenic.正确答案：ABCD第12题Whichofthefollowinggenesisnottranscriptionfactorsaffectingfolliculogenesis?ANR5A1.BAMHR2.CWT1.DFOXL2.第13题WESreferstowholeexomesequencing.第14题Candidategeneapproachisbasedonthegeneexpressionandfunctioninfolliculogenesisorovariandevelopment,orphenotypesofmurineknockoutmodels.第15题Candidategeneapproachcanidentifynovelorlesswell-knowngenesbasedonapriorihypothesisbynow.第16题WhichofthefollowinggenesisnotrelatedwithDNAdamagerepairandhomologousrecombination?AFSHRBMSH5CMCM8DMCM9第17题Prematureovarianinsufficiencyisaclinicalsyndromedefinedbylossofovarianactivitybeforetheageof___.A25B30C40D45第18题RecommendeddiagnosticcriteriaofPOI(Prematureovarianinsufficiency):Oligo/amenorrheaforatleast__monthsandanelevatedFSHlevelexceeding__ontwooccasionsA3,15B3,20C4,20D4,25第19题Duringfemalelifespan,thereare__germcellsatthe20thweekofgestation.A6–7millionB1–2millionC0.5millionD1000Exercises第1题FISHwasdevelopedonthebasisofisotopeinsituhybridization第2题Whichoffollowingsarethepro