AF38469-AF-38469-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAF38469Cat. No.: HY-12802CAS No.: 1531634-31-7Synonyms: AF-38469分式: CHFNO分量: 324.25作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 43 mg/mL (132.61 mM)* means soluble,

2、 but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0840 mL 15.4202 mL 30.8404 mL5 mM 0.6168 mL 3.0840 mL 6.1681 mL10 mM 0.3084 mL 1.5420 mL 3.0840 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 AF38469种新型，具有选择性和服活性的 Sortilin 抑制剂, IC50 值为330 nM。IC50 & T

3、arget IC50:330 nM (Sortilin) 1体外研究AF38469 showed no inhibition or stimulation of 50% at 10 M in a standard selectivity panel of ca. 701/2 Master of Small Molecules 您边的抑制剂师www.MedChemEtargets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In additionAF38469 showed no

4、activity against a selected panel of targets known to bind acidic molecules (d-Opioid,GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an importanttool to further delineate the biology of Sortilin, and to facilitate evaluation of the therapeutic potential of thi

5、sprotein 1.户使本产品发表的科研献 Cell Death Dis. 2019 Feb 27;10(3):208. Breast Cancer Res. 2018 Nov 20;20(1):137.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. BioorgMed Chem Lett. 2014 Jan 1;24(1):177-80.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;