L-plus-Arabinose-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-(+)-ArabinoseCat. No.: HY-W015611CAS No.: 5328-37-0分式: CHO分量: 150.13作靶点: Endogenous Metabolite作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 500 mg/mL (3330.

2、45 mM; Need ultrasonic)DMSO : 50 mg/mL (333.04 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 6.6609 mL 33.3045 mL 66.6089 mL5 mM 1.3322 mL 6.6609 mL 13.3218 mL10 mM 0.6661 mL 3.3304 mL 6.6609 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备

3、液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (16.65 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (16.65 mM); Clear solution3. 请依序添加每种溶剂

4、： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (16.65 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 L-(+)-Arabinose 有选择性的抑制肠道蔗糖酶的活性，并抑制因蔗糖摄导致的浆葡萄糖增加。IC50 & Target Human Endogenous Metabolite体外研究 L-(+)-Arabinose selectively inhibits intestinal sucrase activi

5、ty in a noncompetitive manner and suppresses theplasma glucose increase due to sucrose ingestion 1. L-(+)-Arabinose is found to be associated with ribose-5-phosphate isomerase deficiency, which is an inborn error of metabolism 2.REFERENCES1. Osaki S, et al. L-arabinose feeding prevents increases due

6、 to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats. JNutr. 2001 Mar;131(3):796-9.2. Huck JH, et al. Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowlyprogressive leukoencephalopathy. Am J Hum Genet. 2004 Apr;74(4):745-51.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 4